| Literature DB >> 11594818 |
R U Braun1, K Zeitler, T J Müller.
Abstract
[reaction: see text]. 1,2,3,5-tetrasubstituted pyrroles can be synthesized in good yields in a one-pot, three-step, four-component process by a coupling-isomerization-Stetter reaction-Paal-Knorr sequence of an electron-poor (hetero)aryl halide, a terminal propargyl alcohol, an aldehyde, and a primary amine. The structures of the 1,4-diketone 4f and the pyrrole 6b were additionally supported by X-ray structure analyses.Entities:
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Year: 2001 PMID： 11594818 DOI： 10.1021/ol0165185
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005