| Literature DB >> 15068089 |
Roland U Braun1, Thomas J J Müller.
Abstract
The coupling-isomerization-reaction (CIR) of an electron-deficient halide 1 with 1-(p-bromo phenyl) propyne-1-ol (2) leads to an in-situ activation of the carbon-bromine bond towards oxidative addition and has been elaborated to a consecutive CIR-coupling sequence where subsequent palladium catalyzed coupling reactions such as Sonogashira, CIR, Heck, or Suzuki reactions allow a rapid construction of more complex frameworks in a one-pot reaction and in moderate to good yields.Entities:
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Year: 2003 PMID： 15068089 DOI： 10.1023/b:modi.0000006782.32899.94
Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943