BACKGROUND: Few data exist on the physiological aspects of pig-to-primate renal xenotransplantation. METHODS: Use of organs transgenic for human decay accelerating factor has allowed assessment of the metabolic and hormonal functions of these xenografts. RESULTS: Porcine renal xenografts largely maintain plasma electrolyte homeostasis. An increase in proteinuria was detected that may result from graft injury. In contrast to allotransplantation a severe anaemia developed requiring recipient treatment with exogenous human erythropoietin. CONCLUSIONS: Our experience provides qualified encouragement for the likely physiological compatibility of pig and primate species, but identifies areas where a xenograft may not match the performance of an allograft.
BACKGROUND: Few data exist on the physiological aspects of pig-to-primate renal xenotransplantation. METHODS: Use of organs transgenic for human decay accelerating factor has allowed assessment of the metabolic and hormonal functions of these xenografts. RESULTS: Porcine renal xenografts largely maintain plasma electrolyte homeostasis. An increase in proteinuria was detected that may result from graft injury. In contrast to allotransplantation a severe anaemia developed requiring recipient treatment with exogenous humanerythropoietin. CONCLUSIONS: Our experience provides qualified encouragement for the likely physiological compatibility of pig and primate species, but identifies areas where a xenograft may not match the performance of an allograft.
Authors: Laura Higginbotham; Dave Mathews; Cynthia A Breeden; Mingqing Song; Alton Brad Farris; Christian P Larsen; Mandy L Ford; Andrew J Lutz; Matthew Tector; Kenneth A Newell; A Joseph Tector; Andrew B Adams Journal: Xenotransplantation Date: 2015-04-03 Impact factor: 3.907
Authors: James Russell Butler; Leela L Paris; Ross L Blankenship; Richard A Sidner; Gregory R Martens; Joseph M Ladowski; Ping Li; Jose L Estrada; Matthew Tector; A Joseph Tector Journal: Transplantation Date: 2016-03 Impact factor: 4.939
Authors: Burcin Ekser; John Bianchi; Suyapa Ball; Hayato Iwase; Anneke Walters; Mohamed Ezzelarab; Massimiliano Veroux; Bruno Gridelli; Robert Wagner; David Ayares; David K C Cooper Journal: Xenotransplantation Date: 2012-11-12 Impact factor: 3.907
Authors: Hayato Iwase; Hong Liu; Martin Wijkstrom; Huidong Zhou; Jagjit Singh; Hidetaka Hara; Mohamed Ezzelarab; Cassandra Long; Edwin Klein; Robert Wagner; Carol Phelps; David Ayares; Ron Shapiro; Abhinav Humar; David K C Cooper Journal: Xenotransplantation Date: 2015-06-29 Impact factor: 3.907