| Literature DB >> 11566483 |
T Maoka1, K Mochida, M Kozuka, Y Ito, Y Fujiwara, K Hashimoto, F Enjo, M Ogata, Y Nobukuni, H Tokuda, H Nishino.
Abstract
Capsanthin and related carotenoids isolated from the fruits of red paprika Capsicum annuum L. showed potent in vitro anti-tumor-promoting activity with inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among them, capsanthin diester and capsorbin diester showed strong inhibitory effects. Furthermore, capsanthin , capsanthin 3'-ester and capsanthin 3,3'-diester , major carotenoids in paprika, exhibited potent anti-tumor-promoting activity in an in vivo mouse skin two-stage carcinogenesis assay using 7, 12-dimethylbenz[a]anthracene as an initiator and TPA as a promoter.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11566483 DOI： 10.1016/s0304-3835(01)00635-8
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679