Literature DB >> 27134615

V. Amygdalina: Folk Medicine, Analysis, and Potential Application for Cancer Treatment.

Ernest B Izevbigie1, C B Howard2, K S Lee3.   

Abstract

Folk medicine (FM) is practiced by people without access to conventional medical services; it usually involves the use of natural remedies such as herbs or vegetable substances. Before the use of pharmaceutical drugs, and surgical procedures, these healing methods were used, and are still in use today. It is estimated that twenty five percent of all therapeutic drugs trace their origins to plants, and almost two-thirds of the people of the world rely on their healing powers. One hundred years ago, health care in the U.S. was provided by a highly competitive medical sect, and quite infrequently, folk medicine practitioners were patronized. However, FM usage in the U.S. has increased drastically during the past decade. National surveys of adults (18 years of age or older) show that one in three adults use unconventional therapies or Complementary and Alternative Medicine (CAM) in the U.S. The rate of CAM usage is more than eighty percent among cancer patients. Vernonia amygdalina (VA) is well known for its medicinal importance. Fractionation of the VA extracts with solvents of varying polarities, by silica gels analyses, UV Spectrophotometer, HPLC, TLC and NMR techniques have yielded some biologically-active fractions.

Entities:  

Keywords:  Anti-cancer activity; Apoptosis; Sesquiterpene lactones; Vernonia amygdalina extracts

Year:  2008        PMID: 27134615      PMCID: PMC4850832          DOI: 10.2174/157341208783497579

Source DB:  PubMed          Journal:  Curr Pharm Anal        ISSN: 1573-4129            Impact factor:   0.890


  38 in total

Review 1.  Chemoprotection against cancer by induction of phase 2 enzymes.

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Journal:  Biofactors       Date:  2000       Impact factor: 6.113

Review 2.  Biopharmacologic and herbal therapies for cancer: research update from NCCAM.

Authors:  M A Richardson
Journal:  J Nutr       Date:  2001-11       Impact factor: 4.798

Review 3.  Extracellular signal-regulated kinases: ERKs in progress.

Authors:  M H Cobb; T G Boulton; D J Robbins
Journal:  Cell Regul       Date:  1991-12

4.  Discovery of water-soluble anticancer agents (edotides) from a vegetable found in Benin City, Nigeria.

Authors:  Ernest B Izevbigie
Journal:  Exp Biol Med (Maywood)       Date:  2003-03

Review 5.  Applying science to changing dietary patterns.

Authors:  D Heber; S Bowerman
Journal:  J Nutr       Date:  2001-11       Impact factor: 4.798

6.  Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells.

Authors:  E Mata-Greenwood; A Ito; H Westenburg; B Cui; R G Mehta; A D Kinghorn; J M Pezzuto
Journal:  Anticancer Res       Date:  2001 May-Jun       Impact factor: 2.480

7.  Cytotoxicity of some Russian ethnomedicinal plants and plant compounds.

Authors:  Nikolay A Spiridonov; Dmitrii A Konovalov; Vladimir V Arkhipov
Journal:  Phytother Res       Date:  2005-05       Impact factor: 5.878

8.  A novel natural inhibitor of extracellular signal-regulated kinases and human breast cancer cell growth.

Authors:  Ernest B Izevbigie; Joseph L Bryant; Alice Walker
Journal:  Exp Biol Med (Maywood)       Date:  2004-02

9.  Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines.

Authors:  Jae Youl Cho; Ae Ra Kim; Jee H Jung; Taehoon Chun; Man Hee Rhee; Eun Sook Yoo
Journal:  Eur J Pharmacol       Date:  2004-05-25       Impact factor: 4.432

10.  Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

Authors:  L B Ray; T W Sturgill
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

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  1 in total

1.  Recent perspectives on the anticancer properties of aqueous extracts of Nigerian Vernonia amygdalina.

Authors:  Carolyn Bingham Howard; William K Johnson; Shehla Pervin; Ernest B Izevbigie
Journal:  Botanics       Date:  2015-11-30
  1 in total

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