Literature DB >> 22822380

Anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of nitroastaxanthin and nitrolutein, the reaction products of astaxanthin and lutein with peroxynitrite.

Takashi Maoka1, Harukuni Tokuda2, Nobutaka Suzuki2, Hideaki Kato3, Hideo Etoh3.   

Abstract

Astaxanthin captured peroxynitrite to form nitroastaxanthins. 15-Nitroastaxanthin was a major reaction product of astaxanthin with peroxynitrite. Here, the anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of 15-nitroastaxanthin were investigated. In addition to astaxanthin, 15-nitroastaxanthin showed excellent singlet oxygen quenching activity. Furthermore, 15-nitroastaxanthin showed inhibitory effects of in vitro Epstein-Barr virus early antigen activation and two-stage carcinogensis on mouse skin papillomas. These activities were slightly higher than those of astaxanthin. Similar results were obtained for the 15-nitrolutein, a major reaction product of lutein with peroxynitrite.

Entities:  

Keywords:  15-nitroastaxanthin; 15-nitrolutein; anti-carcinogensis activity; anti-oxidative activity; carotenoid

Mesh：

Substances：

Year:  2012        PMID： 22822380      PMCID： PMC3397447          DOI： 10.3390/md10061391

Source DB:  PubMed          Journal:  Mar Drugs        ISSN： 1660-3397            Impact factor:   6.085


  11 in total

1.  Antioxidative properties of phenolic antioxidants isolated from corn steep liquor.

Authors:  T Niwa; U Doi; Y Kato; T Osawa
Journal:  J Agric Food Chem       Date:  2001-01       Impact factor: 5.279

2.  Characterization and antioxidative activities of rare C(50) carotenoids-sarcinaxanthin, sarcinaxanthin monoglucoside, and sarcinaxanthin diglucoside-obtained from Micrococcus yunnanensis.

Authors:  Ayako Osawa; Yoko Ishii; Nao Sasamura; Marie Morita; Hiroaki Kasai; Takashi Maoka; Kazutoshi Shindo
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Review 3.  Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?

Authors:  B Halliwell
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4.  Mechanism for the peroxynitrite scavenging activity by anthocyanins.

Authors:  T Tsuda; Y Kato; T Osawa
Journal:  FEBS Lett       Date:  2000-11-10       Impact factor: 4.124

5.  Nitrocapsanthin and nitrofucoxanthin, respective products of capsanthin and fucoxanthin reaction with peroxynitrite.

Authors:  Makoto Tsuboi; Hideo Etoh; Kyuki Kato; Hiroki Nakatugawa; Hideki Kato; Yasunori Maejima; Gaku Matsumoto; Hironobu Mori; Masashi Hosokawa; Kazuo Miyashita; Harukuni Tokuda; Nobukuni Suzuki; Takashi Maoka
Journal:  J Agric Food Chem       Date:  2011-09-19       Impact factor: 5.279

6.  The effect of alpha-tocopherol on the nitration of gamma-tocopherol by peroxynitrite.

Authors:  S P Goss; N Hogg; B Kalyanaraman
Journal:  Arch Biochem Biophys       Date:  1999-03-15       Impact factor: 4.013

7.  Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation.

Authors:  Seon-Jin Lee; Se-Kyung Bai; Kwang-Soon Lee; Seung Namkoong; Hee-Jun Na; Kwon-Soo Ha; Jeong-A Han; Sung-Vin Yim; Kwang Chang; Young-Guen Kwon; Sung Ki Lee; Young-Myeong Kim
Journal:  Mol Cells       Date:  2003-08-31       Impact factor: 5.034

8.  Singlet oxygen quenching ability of naturally occurring carotenoids.

Authors:  O Hirayama; K Nakamura; S Hamada; Y Kobayasi
Journal:  Lipids       Date:  1994-02       Impact factor: 1.880

9.  Reaction of astaxanthin with peroxynitrite.

Authors:  Tsutomu Hayakawa; Aditya Kulkarni; Yukimasa Terada; Takashi Maoka; Hideo Etoh
Journal:  Biosci Biotechnol Biochem       Date:  2008-10-07       Impact factor: 2.043

10.  Inhibitory effect of natural carotenoids on Epstein-Barr virus activation activity of a tumor promoter in Raji cells. A screening study for anti-tumor promoters.

Authors:  M Tsushima; T Maoka; M Katsuyama; M Kozuka; T Matsuno; H Tokuda; H Nishino; A Iwashima
Journal:  Biol Pharm Bull       Date:  1995-02       Impact factor: 2.233
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  13 in total

1.  Evaluation of hepatoprotective and antioxidant activity of astaxanthin and astaxanthin esters from microalga-Haematococcus pluvialis.

Authors:  A Ranga Rao; R Sarada; M D Shylaja; G A Ravishankar
Journal:  J Food Sci Technol       Date:  2015-03-05       Impact factor: 2.701

2.  Proteomic investigation of the sinulariolide-treated melanoma cells A375: effects on the cell apoptosis through mitochondrial-related pathway and activation of caspase cascade.

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Journal:  Mar Drugs       Date:  2013-07-22       Impact factor: 5.118

3.  Sinulariolide Suppresses Human Hepatocellular Carcinoma Cell Migration and Invasion by Inhibiting Matrix Metalloproteinase-2/-9 through MAPKs and PI3K/Akt Signaling Pathways.

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Review 4.  Astaxanthin: sources, extraction, stability, biological activities and its commercial applications--a review.

Authors:  Ranga Rao Ambati; Siew Moi Phang; Sarada Ravi; Ravishankar Gokare Aswathanarayana
Journal:  Mar Drugs       Date:  2014-01-07       Impact factor: 5.118

5.  Astaxanthin inhibits JAK/STAT-3 signaling to abrogate cell proliferation, invasion and angiogenesis in a hamster model of oral cancer.

Authors:  J Kowshik; Abdul Basit Baba; Hemant Giri; G Deepak Reddy; Madhulika Dixit; Siddavaram Nagini
Journal:  PLoS One       Date:  2014-10-08       Impact factor: 3.240

Review 6.  Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer.

Authors:  Elena Talero; Sofía García-Mauriño; Javier Ávila-Román; Azahara Rodríguez-Luna; Antonio Alcaide; Virginia Motilva
Journal:  Mar Drugs       Date:  2015-09-30       Impact factor: 5.118

Review 7.  Vascular and Neuronal Protection in the Developing Retina: Potential Therapeutic Targets for Retinopathy of Prematurity.

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Review 8.  Carotenoids from Marine Microalgae: A Valuable Natural Source for the Prevention of Chronic Diseases.

Authors:  Maria Filomena de Jesus Raposo; Alcina Maria Miranda Bernardo de Morais; Rui Manuel Santos Costa de Morais
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Review 9.  Marine low molecular weight natural products as potential cancer preventive compounds.

Authors:  Valentin A Stonik; Sergey N Fedorov
Journal:  Mar Drugs       Date:  2014-01-27       Impact factor: 5.118

10.  Ulinastatin inhibits renal tubular epithelial apoptosis and interstitial fibrosis in rats with unilateral ureteral obstruction.

Authors:  Qing-Fang Zhang
Journal:  Mol Med Rep       Date:  2017-10-03       Impact factor: 2.952
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