BACKGROUND: The Cleveland Clinic CorAide left ventricular assist system is based on a small implantable continuous-flow centrifugal blood pump with a completely suspended rotating assembly designed for long-term circulatory support (5 to 10 years). METHODS: Between June 1999 and August 2000, the CorAide blood pump was implanted in 10 calves for 1 month and in 3 calves for 3 months. RESULTS: The mean pump flow and arterial pressure were 6.1 +/- 1.1 L/min and 97 +/- 5 mm Hg, respectively. The mean plasma free-hemoglobin level after postoperative day 3 was 2.0 +/- 1.8 mg/dL. Renal and hepatic function remained normal in all cases. There was no incidence of mechanical failure, hemolysis, bleeding, or systemic organ dysfunction in any of the cases. Significant findings at autopsy were limited to two cases of renal infarction, one of which was associated with an outflow graft infection. CONCLUSIONS: The CorAide blood pump is easily implanted, reliable, nonhemolytic, and nonthrombogenic, positioning it as a leading third-generation, continuous-flow left ventricular assist system with a completely suspended rotor.
BACKGROUND: The Cleveland Clinic CorAide left ventricular assist system is based on a small implantable continuous-flow centrifugal blood pump with a completely suspended rotating assembly designed for long-term circulatory support (5 to 10 years). METHODS: Between June 1999 and August 2000, the CorAide blood pump was implanted in 10 calves for 1 month and in 3 calves for 3 months. RESULTS: The mean pump flow and arterial pressure were 6.1 +/- 1.1 L/min and 97 +/- 5 mm Hg, respectively. The mean plasma free-hemoglobin level after postoperative day 3 was 2.0 +/- 1.8 mg/dL. Renal and hepatic function remained normal in all cases. There was no incidence of mechanical failure, hemolysis, bleeding, or systemic organ dysfunction in any of the cases. Significant findings at autopsy were limited to two cases of renal infarction, one of which was associated with an outflow graft infection. CONCLUSIONS: The CorAide blood pump is easily implanted, reliable, nonhemolytic, and nonthrombogenic, positioning it as a leading third-generation, continuous-flow left ventricular assist system with a completely suspended rotor.
Authors: Yoshio Ootaki; Keiji Kamohara; Masatoshi Akiyama; Firas Zahr; Michael W Kopcak; Raymond Dessoffy; Alex Massiello; David Horvath; Ji-Feng Chen; Stephen Benefit; Leonard A R Golding; Kiyotaka Fukamachi Journal: ASAIO J Date: 2005 Nov-Dec Impact factor: 2.872
Authors: Kiyotaka Fukamachi; David J Horvath; Alex L Massiello; Yoshio Ootaki; Keiji Kamohara; Masatoshi Akiyama; Firas Zahr; Michael W Kopcak; Raymond Dessoffy; Ji-Feng Chen; Stephen Benefit; Leonard A R Golding Journal: ASAIO J Date: 2005 Nov-Dec Impact factor: 2.872
Authors: Kiyotaka Fukamachi; Akira Shiose; Alex L Massiello; David J Horvath; Leonard A R Golding; Sangjin Lee; Randall C Starling Journal: Ann Thorac Surg Date: 2012-03-27 Impact factor: 4.330