Literature DB >> 11563116

Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity.

J Wang1, B Verbeure, I Luyten, M Froeyen, C Hendrix, H Rosemeyer, F Seela, A Van Aerschot, P Herdewijn.   

Abstract

Cyclohexene nucleic acids (CeNA) were synthesized using classical phosporamidite chemistry. Incorporation of a cyclohexene nucleo-side in a DNA chain leads to an increase in stability of the DNA/RNA duplex. CeNA is stable against degradation in serum. A CeNA/RNA hybrid is able to activate E. Coli RNase H. resulting in cleavage of the RNA strand.

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Year:  2001        PMID： 11563116     DOI： 10.1081/NCN-100002430

Source DB:  PubMed          Journal:  Nucleosides Nucleotides Nucleic Acids        ISSN： 1525-7770            Impact factor:   1.381


  4 in total

Review 1.  Non-natural nucleic acids for synthetic biology.

Authors:  Daniel H Appella
Journal:  Curr Opin Chem Biol       Date:  2009-10-29       Impact factor: 8.822

2.  Cyclohexenyl nucleic acids: conformationally flexible oligonucleotides.

Authors:  Koen Nauwelaerts; Eveline Lescrinier; Gert Sclep; Piet Herdewijn
Journal:  Nucleic Acids Res       Date:  2005-04-29       Impact factor: 16.971

Review 3.  Recent progress toward the templated synthesis and directed evolution of sequence-defined synthetic polymers.

Authors:  Yevgeny Brudno; David R Liu
Journal:  Chem Biol       Date:  2009-03-27

4.  5'-O-Methylphosphonate nucleic acids--new modified DNAs that increase the Escherichia coli RNase H cleavage rate of hybrid duplexes.

Authors:  Hana Šipova; Tomaš Špringer; Dominik Rejman; Ondřej Šimak; Magdalena Petrová; Pavel Novák; Šarka Rosenbergová; Ondřej Páv; Radek Liboska; Ivan Barvík; Josef Štěpanek; Ivan Rosenberg; Jiři Homola
Journal:  Nucleic Acids Res       Date:  2014-02-12       Impact factor: 16.971
  4 in total

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