| Literature DB >> 18404327 |
Pranorm Khaomek1, Chikara Ichino, Aki Ishiyama, Hitomi Sekiguchi, Miyuki Namatame, Nijsiri Ruangrungsi, Ekarin Saifah, Hiroaki Kiyohara, Kazuhiko Otoguro, Satoshi Omura, Haruki Yamada.
Abstract
Ethyl acetate (EtOAc) extract from the stem bark of Erythrina fusca showed a antimalarial activity against the multi-drug-resistant strain (K1) of Plasmodium falciparum, and six flavonoids, lupinifolin (1), citflavanone (2), erythrisenegalone (3), lonchocarpol A (4), liquiritigenin (5), and 8-prenyldaidzein (6), were isolated from the extract. Diprenylated flavanone 4 showed a notable antimalarial activity (IC(50); 1.6 microg/mL); however 1 and 3 did not show the activity, even though these compounds possessed prenylated substitution.Entities:
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Year: 2008 PMID: 18404327 DOI: 10.1007/s11418-007-0214-z
Source DB: PubMed Journal: J Nat Med ISSN: 1340-3443 Impact factor: 2.343