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Literature DB >> 11538679

Model of early self-replication based on covalent complementarity for a copolymer of glycerate-3-phosphate and glycerol-3-phosphate.

Abstract

Glyceraldehyde-3-phosphate acts as the substrate in a model of early self-replication of a phosphodiester copolymer of glycerate-3-phosphate and glycerol-3-phosphate. This model of self-replication is based on covalent complementarity in which information transfer is mediated by a single covalent bond, in contrast to multiple weak interactions that establish complementarity in nucleic acid replication. This replication model is connected to contemporary biochemistry through its use of glyceraldehyde-3-phosphate, a central metabolite of glycolysis and photosynthesis.

Entities: Chemical

Keywords: NASA Discipline Exobiology; NASA Discipline Number 52-20; NASA Program Exobiology; Non-NASA Center

Mesh：

Substances：

Year: 1989 PMID： 11538679 DOI： 10.1007/bf01808151

Source DB: PubMed Journal: Orig Life Evol Biosph ISSN： 0169-6149 Impact factor: 1.950

15 in total

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Journal: Cold Spring Harb Perspect Biol Date: 2012-05-01 Impact factor: 10.005

Review 3. The first living systems: a bioenergetic perspective.

Authors: D W Deamer
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3 in total

Model of early self-replication based on covalent complementarity for a copolymer of glycerate-3-phosphate and glycerol-3-phosphate.

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3. Energy conservation in chemotrophic anaerobic bacteria.

Review 4. Evolution of the genetic apparatus: a review.

5. RNA evolution and the origins of life.

6. The case for an ancestral genetic system involving simple analogues of the nucleotides.

7. Physical properties of poly- -hydroxybutyrate. IV. Conformational analysis and crystalline structure.

8. The triose model: glyceraldehyde as a source of energy and monomers for prebiotic condensation reactions.

9. Nonenzymatic formation of "energy-rich" lactoyl and glyceroyl thioesters from glyceraldehyde and a thiol.

10. Formation of pyrophosphate on hydroxyapatite with thioesters as condensing agents.

1. Nucleic acid duplexes incorporating a dissociable covalent base pair.

Review 2. The origins of the RNA world.

Review 3. The first living systems: a bioenergetic perspective.