Literature DB >> 3627761

The triose model: glyceraldehyde as a source of energy and monomers for prebiotic condensation reactions.

A L Weber.   

Abstract

Glyceraldehyde acts as a source of energy and monomers in a new model of the origin of life. The simplest form of the model functions by converting formaldehyde from the environment into glyceraldehyde which spontaneously forms hemiacetal adducts that are oxidized to polyglyceric acid. Polyglyceric acid, in turn, acts as an autocatalyst with a rudimentary replicating ability. A unique property of the model is its ability to unite the origin of metabolism and the origin of polymer synthesis into a single process. Furthermore, the chemical resemblance of the model to glycolysis gives it the potential to develop a biological metabolism in a straightforward manner.

Entities:  

Keywords:  NASA Discipline Exobiology; Non-NASA Center

Mesh:

Substances:

Year:  1987        PMID: 3627761     DOI: 10.1007/BF01808239

Source DB:  PubMed          Journal:  Orig Life Evol Biosph        ISSN: 0169-6149            Impact factor:   1.950


  26 in total

1.  Alanine synthesis from glyceraldehyde and ammonium ion in aqueous solution.

Authors:  A L Weber
Journal:  J Mol Evol       Date:  1985       Impact factor: 2.395

2.  The formation of organic compounds on the primitive earth.

Authors:  S L MILLER
Journal:  Ann N Y Acad Sci       Date:  1957-08-30       Impact factor: 5.691

3.  Reduction of carbon dioxide in aqueous solutions by ionizing radiation.

Authors:  W M GARRISON; D C MORRISON; J G HAMILTON; A A BENSON; M CALVIN
Journal:  Science       Date:  1951-10-19       Impact factor: 47.728

4.  Base-catalyzed beta-elimination reactions in aqueous solution. I. Elimination from beta-acetoxy ketones.

Authors:  L R Fedor
Journal:  J Am Chem Soc       Date:  1967-08-16       Impact factor: 15.419

5.  Abiotic origin of biopolymers.

Authors:  J Oró; E Stephen-Sherwood
Journal:  Orig Life       Date:  1976-01

6.  Prebiotic condensation reactions in an aqueous medium: a review of condensing agents.

Authors:  J Hulshof; C Ponnamperuma
Journal:  Orig Life       Date:  1976-08

7.  Model for origin of monosaccharides.

Authors:  N W Gabel; C Ponnamperuma
Journal:  Nature       Date:  1967-11-04       Impact factor: 49.962

8.  Nonenzymatic formation of "energy-rich" lactoyl and glyceroyl thioesters from glyceraldehyde and a thiol.

Authors:  A L Weber
Journal:  J Mol Evol       Date:  1984       Impact factor: 2.395

9.  Spontaneous N epsilon-methylation and N epsilon-formylation reactions between L-lysine and formaldehyde inhibited by L-ascorbic acid.

Authors:  L Trézl; I Rusznák; E Tyihák; T Szarvas; B Szende
Journal:  Biochem J       Date:  1983-08-15       Impact factor: 3.857

10.  Photochemical Production of Formaldehyde in Earth's Primitive Atmosphere.

Authors:  J P Pinto; G R Gladstone; Y L Yung
Journal:  Science       Date:  1980-10-10       Impact factor: 47.728

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  22 in total

1.  Prebiotic synthesis of vitamin B6-type compounds.

Authors:  S M Austin; T G Waddell
Journal:  Orig Life Evol Biosph       Date:  1999-05       Impact factor: 1.950

2.  Origin of fatty acid synthesis: thermodynamics and kinetics of reaction pathways.

Authors:  A L Weber
Journal:  J Mol Evol       Date:  1991       Impact factor: 2.395

3.  Oligoglyceric acid synthesis by autocondensation of glyceroyl thioester.

Authors:  A L Weber
Journal:  J Mol Evol       Date:  1987       Impact factor: 2.395

4.  Sugars as the optimal biosynthetic carbon substrate of aqueous life throughout the universe.

Authors:  A L Weber
Journal:  Orig Life Evol Biosph       Date:  2000-02       Impact factor: 1.950

Review 5.  The origins of the RNA world.

Authors:  Michael P Robertson; Gerald F Joyce
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-05-01       Impact factor: 10.005

6.  The role of carbohydrates at the origin of homochirality in biosystems.

Authors:  Søren Toxvaerd
Journal:  Orig Life Evol Biosph       Date:  2013-08-31       Impact factor: 1.950

7.  Kinetics of organic transformations under mild aqueous conditions: implications for the origin of life and its metabolism.

Authors:  Arthur L Weber
Journal:  Orig Life Evol Biosph       Date:  2004-10       Impact factor: 1.950

Review 8.  The origin and amplification of biomolecular chirality.

Authors:  W A Bonner
Journal:  Orig Life Evol Biosph       Date:  1991       Impact factor: 1.950

Review 9.  Mirror symmetry breaking at the molecular level.

Authors:  V Avetisov; V Goldanskii
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

Review 10.  On the free energy that drove primordial anabolism.

Authors:  Michael Kaufmann
Journal:  Int J Mol Sci       Date:  2009-04-22       Impact factor: 6.208

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