Literature DB >> 11538257

Disulfide-linked oligonucleotide phosphorothioates: novel analogues of nucleic acids.

T Wu1, L E Orgel.   

Abstract

The synthesis of phosphorothioate analogues of oligonucleotides by the oxidation of deoxyadenosine 3',5'-bisphosphorothioate (3) was attempted. Cyclization of 3 is much more efficient than oligomerization under all the conditions investigated. However, a preformed oligonucleotide carrying a 5'-terminal phosphorothioate group undergoes efficient chain-extension when oxidized in the presence of 3.

Entities:  

Keywords:  NASA Discipline Exobiology; NASA Discipline Number 52-20; NASA Program Exobiology; Non-NASA Center

Mesh：

Substances：

Year:  1991        PMID： 11538257     DOI： 10.1007/bf02102183

Source DB:  PubMed          Journal:  J Mol Evol        ISSN： 0022-2844            Impact factor:   2.395


  6 in total

1.  The case for an ancestral genetic system involving simple analogues of the nucleotides.

Authors:  G F Joyce; A W Schwartz; S L Miller; L E Orgel
Journal:  Proc Natl Acad Sci U S A       Date:  1987-07       Impact factor: 11.205

2.  Cyclization of nucleotide analogues as an obstacle to polymerization.

Authors:  A R Hill; L D Nord; L E Orgel; R K Robins
Journal:  J Mol Evol       Date:  1988 Dec-1989 Feb       Impact factor: 2.395

3.  A simple procedure for cross-linking complementary oligonucleotides.

Authors:  B C Chu; L E Orgel
Journal:  DNA Cell Biol       Date:  1990 Jan-Feb       Impact factor: 3.311

4.  Template-directed oligomerization catalyzed by a polynucleotide analog.

Authors:  J Visscher; C G Bakker; R van der Woerd; A W Schwartz
Journal:  Science       Date:  1989-04-21       Impact factor: 47.728

5.  Autocatalytic synthesis of a tetranucleotide analogue.

Authors:  W S Zielinski; L E Orgel
Journal:  Nature       Date:  1987 May 28-Jun 3       Impact factor: 49.962

6.  Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates.

Authors:  G F Joyce; T Inoue; L E Orgel
Journal:  J Mol Biol       Date:  1984-06-25       Impact factor: 5.469
  6 in total
  4 in total

1.  Maleimide-mediated protein conjugates of a nucleoside triphosphate gamma-S and an internucleotide phosphorothioate diester.

Authors:  A S Karim; C S Johansson; J K Weltman
Journal:  Nucleic Acids Res       Date:  1995-06-11       Impact factor: 16.971

Review 2.  Biology by design: from top to bottom and back.

Authors:  Brian R Fritz; Laura E Timmerman; Nichole M Daringer; Joshua N Leonard; Michael C Jewett
Journal:  J Biomed Biotechnol       Date:  2010-11-02

3.  Template controlled coupling and recombination of oligonucleotide blocks containing thiophosphoryl groups.

Authors:  S M Gryaznov; R L Letsinger
Journal:  Nucleic Acids Res       Date:  1993-03-25       Impact factor: 16.971

4.  DNA Phosphorothioate Modification Plays a Role in Peroxides Resistance in Streptomyces lividans.

Authors:  Daofeng Dai; Aiqin Du; Kangli Xiong; Tianning Pu; Xiufen Zhou; Zixin Deng; Jingdan Liang; Xinyi He; Zhijun Wang
Journal:  Front Microbiol       Date:  2016-08-31       Impact factor: 5.640
  4 in total

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