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Literature DB >> 3148737

Cyclization of nucleotide analogues as an obstacle to polymerization.

A R Hill¹, L D Nord, L E Orgel, R K Robins.

Abstract

Cyclization of activated nucleotide analogues by intramolecular phosphodiester-bond formation is likely to compete very effectively with template-directed condensation except in the cases of ribo- and arabinonucleotides. This could have excluded derivatives of most sugars from growing polyribonucleotide chains and thus reduced chain-termination in prebiotic polynucleotide synthesis.

Entities: Chemical

Keywords: NASA Discipline Exobiology; Non-NASA Center

Mesh：

Substances：

Year: 1988 PMID： 3148737 DOI： 10.1007/bf02143509

Source DB: PubMed Journal: J Mol Evol ISSN： 0022-2844 Impact factor: 2.395

6 in total

Review 1. Evolution of the genetic apparatus: a review.

Authors: L E Orgel
Journal: Cold Spring Harb Symp Quant Biol Date: 1987

2. The case for an ancestral genetic system involving simple analogues of the nucleotides.

Authors: G F Joyce; A W Schwartz; S L Miller; L E Orgel
Journal: Proc Natl Acad Sci U S A Date: 1987-07 Impact factor: 11.205

3. Studies of oligoadenylate formation on a poly (U) template.

Authors: R Lohrmann; L E Orgel
Journal: J Mol Evol Date: 1979-03-15 Impact factor: 2.395

4. Nucleic acid-like structures. II. Polynucleotide analogues as possible primitive precursors of nucleic acids.

Authors: A W Schwartz; J Visscher; C G Bakker; J Niessen
Journal: Orig Life Evol Biosph Date: 1987 Impact factor: 1.950

5. Synthesis, structure, and biological activity of certain 2-deoxy-beta-D-ribo-hexopyranosyl nucleosides and nucleotides.

Authors: L D Nord; N K Dalley; P A McKernan; R K Robins
Journal: J Med Chem Date: 1987-06 Impact factor: 7.446

6. Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates.

Authors: G F Joyce; T Inoue; L E Orgel
Journal: J Mol Biol Date: 1984-06-25 Impact factor: 5.469

6 in total

14 in total

Review 1. The origins of cellular life.

Authors: Jason P Schrum; Ting F Zhu; Jack W Szostak
Journal: Cold Spring Harb Perspect Biol Date: 2010-05-19 Impact factor: 10.005

2. Catalysis and prebiotic RNA synthesis.

Authors: J P Ferris
Journal: Orig Life Evol Biosph Date: 1993-12 Impact factor: 1.950

3. Manganese-catalyzed oligomerizations of nucleotide analogs.

Authors: J Visscher; A W Schartz
Journal: J Mol Evol Date: 1989-10 Impact factor: 2.395

4. Clay catalysis of oligonucleotide formation: kinetics of the reaction of the 5'-phosphorimidazolides of nucleotides with the non-basic heterocycles uracil and hypoxanthine.

Authors: K Kawamura; J P Ferris
Journal: Orig Life Evol Biosph Date: 1999-12 Impact factor: 1.950

5. Polymerization of the cyclic pyrophosphates of nucleosides and their analogues.

Authors: M Tohidi; L E Orgel
Journal: J Mol Evol Date: 1990 Impact factor: 2.395

6. Oligomerization reactions of deoxyribonucleotides on montmorillonite clay: the effect of mononucleotide structure on phosphodiester bond formation.

Authors: J P Ferris
Journal: Orig Life Evol Biosph Date: 1989 Impact factor: 1.950

10. Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers.

Authors: Jason P Schrum; Alonso Ricardo; Mathangi Krishnamurthy; J Craig Blain; Jack W Szostak
Journal: J Am Chem Soc Date: 2009-10-14 Impact factor: 15.419