Literature DB >> 11530805

Involvement of the NUP98 gene in a chromosomal translocation t(11;20)(p15;q11.2) in a patient with acute monocytic leukemia (FAB-M5b).

N Kakazu1, I Shinzato, Y Arai, S Gotoh, A Matsushita, T Ishikawa, K Nagai, T Takahashi, T Ohno, T Tsuchiya, M Ohki, T Abe.   

Abstract

We report here a case of acute monocytic leukemia (M5b subtype according to the French-American-British [FAB] classification) with chromosomal translocation t(11;20)(p15;q11.2). Fluorescence in situ hybridization analysis with a probe for the NUP98 gene, which is located at chromosome band 11p15, showed that the probe hybridized to both derivative chromosomes 11 and 20 as well as to the remaining normal chromosome 11, indicating that the NUP98 gene was split and involved in this translocation. This is the first report of t(11;20)(p15;q11.2) involving the NUP98 gene in overt leukemia.

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Year:  2001        PMID： 11530805     DOI： 10.1007/BF02982549

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  10 in total

1.  The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10.

Authors:  Y Arai; F Hosoda; H Kobayashi; K Arai; Y Hayashi; N Kamada; Y Kaneko; M Ohki
Journal:  Blood       Date:  1997-06-01       Impact factor: 22.113

2.  NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15).

Authors:  T Nakamura; Y Yamazaki; Y Hatano; I Miura
Journal:  Blood       Date:  1999-07-15       Impact factor: 22.113

3.  Combined spectral karyotyping and DAPI banding analysis of chromosome abnormalities in myelodysplastic syndrome.

Authors:  N Kakazu; M Taniwaki; S Horiike; K Nishida; T Tatekawa; M Nagai; T Takahashi; T Akaogi; J Inazawa; M Ohki; T Abe
Journal:  Genes Chromosomes Cancer       Date:  1999-12       Impact factor: 5.006

4.  Inversion of chromosome 11 inv(11)(p15q22), as a recurring chromosomal aberration associated with de novo and secondary myeloid malignancies: identification of a P1 clone spanning the 11q22 breakpoint.

Authors:  H Kobayashi; Y Arai; F Hosoda; N Maseki; Y Hayashi; H Eguchi; M Ohki; Y Kaneko
Journal:  Genes Chromosomes Cancer       Date:  1997-07       Impact factor: 5.006

5.  The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion.

Authors:  H G Ahuja; C A Felix; P D Aplan
Journal:  Blood       Date:  1999-11-01       Impact factor: 22.113

6.  The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia.

Authors:  D J Hussey; M Nicola; S Moore; G B Peters; A Dobrovic
Journal:  Blood       Date:  1999-09-15       Impact factor: 22.113

7.  A new specific chromosomal rearrangement, t(11;20)(p15;q11), in myeloblastic leukemia with maturation.

Authors:  F Mitelman; E L Prigogina; E W Fleischman; M A Frenkel; S Garwicz; S Heim; G W Ilyinskaya; U Kristoffersson; N Mandahl; M A Volkova
Journal:  Leukemia       Date:  1988-07       Impact factor: 11.528

8.  NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia.

Authors:  S Z Raza-Egilmez; S N Jani-Sait; M Grossi; M J Higgins; T B Shows; P D Aplan
Journal:  Cancer Res       Date:  1998-10-01       Impact factor: 12.701

9.  Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia.

Authors:  T Nakamura; D A Largaespada; M P Lee; L A Johnson; K Ohyashiki; K Toyama; S J Chen; C L Willman; I M Chen; A P Feinberg; N A Jenkins; N G Copeland; J D Shaughnessy
Journal:  Nat Genet       Date:  1996-02       Impact factor: 38.330

10.  The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9.

Authors:  J Borrow; A M Shearman; V P Stanton; R Becher; T Collins; A J Williams; I Dubé; F Katz; Y L Kwong; C Morris; K Ohyashiki; K Toyama; J Rowley; D E Housman
Journal:  Nat Genet       Date:  1996-02       Impact factor: 38.330
  10 in total
  1 in total

1.  Bioinformatic prediction and functional characterization of human KIAA0100 gene.

Authors:  He Cui; Xi Lan; Shemin Lu; Fujun Zhang; Wanggang Zhang
Journal:  J Pharm Anal       Date:  2016-11-02
  1 in total

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