| Literature DB >> 8563754 |
J Borrow1, A M Shearman, V P Stanton, R Becher, T Collins, A J Williams, I Dubé, F Katz, Y L Kwong, C Morris, K Ohyashiki, K Toyama, J Rowley, D E Housman.
Abstract
The t(7;11)(p15;p15) translocation is a recurrent chromosomal abnormality associated primarily with acute myeloid leukaemia (FAB M2 and M4). We present here the molecular definition of this translocation. On chromosome 7 positional cloning revealed the consistent rearrangement of the HOXA9 gene, which encodes a class I homeodomain protein potentially involved in myeloid differentiation. On chromosome 11 the translocation targets the human homologue of NUP98, a member of the GLFG nucleoporin family. Chimaeric messages spliced over the breakpoint fuse the GLFG repeat domains of NUP98 in-frame to the HOXA9 homeobox. The predicted NUP98-HOXA9 fusion protein may promote leukaemogenesis through inhibition of HOXA9-mediated terminal differentiation and/or aberrant nucleocytoplasmic transport.Entities:
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Year: 1996 PMID： 8563754 DOI： 10.1038/ng0296-159
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330