Literature DB >> 11527731

A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives.

G Fan1, W Mar, M K Park, E W Choi, K Kim, S Kim.   

Abstract

A series of umbelliferone derivatives was prepared and their 5alpha-reductase type 1 inhibitory activities were evaluated in cell culture systems. Our studies have identified a new series of potent 5alpha-reductase type 1 inhibitors and provided the basis for further development for the treatment of human endocrine disorders associated with overproduction of DHT by 5alpha-reductase type 1. The preliminary structure-activity relationship was described to elucidate the essential structural requirements.

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Year:  2001        PMID： 11527731     DOI： 10.1016/s0960-894x(01)00429-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Synthesis, and Fluorescence Properties of Coumarin and Benzocoumarin Derivatives Conjugated Pyrimidine Scaffolds for Biological Imaging Applications.

Authors:  Najim A Al-Masoudi; Niran J Al-Salihi; Yossra A Marich; Timo Markus
Journal:  J Fluoresc       Date:  2015-10-19       Impact factor: 2.217

2.  Fe3O4@C@OSO3H as an efficient, recyclable magnetic nanocatalyst in Pechmann condensation: green synthesis, characterization, and theoretical study.

Authors:  Zahra Samiei; Somayeh Soleimani-Amiri; Zahra Azizi
Journal:  Mol Divers       Date:  2020-01-11       Impact factor: 2.943

3.  Methyl rac-(2R,11S,12R)-12-(2-chloro-phen-yl)-22-oxo-9,13,21-trioxapenta-cyclo-[12.8.0.0.0.0]docosa-1(14),3,5,7,15(20),16,18-hepta-ene-11-carboxyl-ate.

Authors:  K Swaminathan; K Sethusankar; G Sivakumar; M Bakthadoss
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-09-17

4.  Silica-ZnCl 2 : An Efficient Catalyst for the Synthesis of 4-Methylcoumarins.

Authors:  Bandita Datta; Mohamed Afzal Pasha
Journal:  ISRN Org Chem       Date:  2013-12-16

5.  Virtualizing the p-ANAPL library: a step towards drug discovery from African medicinal plants.

Authors:  Fidele Ntie-Kang; Pascal Amoa Onguéné; Ghislain W Fotso; Kerstin Andrae-Marobela; Merhatibeb Bezabih; Jean Claude Ndom; Bonaventure T Ngadjui; Abiodun O Ogundaini; Berhanu M Abegaz; Luc Mbaze Meva'a
Journal:  PLoS One       Date:  2014-03-05       Impact factor: 3.240

6.  Nanoparticles Based on Novel Carbohydrate-Functionalized Polymers.

Authors:  Cláudia D Raposo; Cristiano A Conceição; M Teresa Barros
Journal:  Molecules       Date:  2020-04-10       Impact factor: 4.411
  6 in total

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