Literature DB >> 1150745

Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential.

T H Norwood, W R Pendergrass, G M Martin.   

Abstract

Postreplicative, "senescent" human fibroblasts were fused to HeLa or to SV-40 transformed human fibroblasts with Sendai virus. DNA synthesis was reinitiated in senescent nuclei in a high proportion of the heterodikaryons. The [3H]thymidine labeling index of senescent fibroblast nuclei in heteropolykaryons was a function of the ratio of HeLa to senescent nuclei.

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 1150745      PMCID： PMC2109544          DOI： 10.1083/jcb.64.3.551

Source DB:  PubMed          Journal:  J Cell Biol        ISSN： 0021-9525            Impact factor:   10.539


  23 in total

1.  THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS.

Authors:  L HAYFLICK
Journal:  Exp Cell Res       Date:  1965-03       Impact factor: 3.905

2.  The maintenance of the accuracy of protein synthesis and its relevance to ageing.

Authors:  L E ORGEL
Journal:  Proc Natl Acad Sci U S A       Date:  1963-04       Impact factor: 11.205

3.  Nucleo-cytoplasmic protein migration during the activation of chick erythrocyte nuclei in heterokaryons.

Authors:  S A Carlsson; G P Moore; N R Ringertz
Journal:  Exp Cell Res       Date:  1973-01       Impact factor: 3.905

4.  Transformation assay for murine sarcoma viruses using a Simian virus 40-transformed human cell line.

Authors:  G J Todaro; C A Meyer
Journal:  J Natl Cancer Inst       Date:  1974-01       Impact factor: 13.506

5.  Clonal senescence and atherosclerosis.

Authors:  G M Martin; C A Sprague
Journal:  Lancet       Date:  1972-12-23       Impact factor: 79.321

Review 6.  The biology of human aging.

Authors:  L Hayflick
Journal:  Am J Med Sci       Date:  1973-06       Impact factor: 2.378

7.  Lifespan of cultured cells in progeria.

Authors:  S Goldstein
Journal:  Lancet       Date:  1969-02-22       Impact factor: 79.321

8.  Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

Authors:  G M Martin; C A Sprague; C J Epstein
Journal:  Lab Invest       Date:  1970-07       Impact factor: 5.662

9.  Dominance of the senescent phenotype in heterokaryons between replicative and post-replicative human fibroblast-like cells.

Authors:  T H Norwood; W R Pendergrass; C A Sprague; G M Martin
Journal:  Proc Natl Acad Sci U S A       Date:  1974-06       Impact factor: 11.205

10.  Artificial heterokaryons of animal cells from different species.

Authors:  H Harris; J F Watkins; C E Ford; G I Schoefl
Journal:  J Cell Sci       Date:  1966-03       Impact factor: 5.285
View more
  12 in total

1.  Membrane-associated inhibitor of DNA synthesis in senescent human diploid fibroblasts: characterization and comparison to quiescent cell inhibitor.

Authors:  G H Stein; L Atkins
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

2.  Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts.

Authors:  C K Lumpkin; J E Knepper; J S Butel; J R Smith; O M Pereira-Smith
Journal:  Mol Cell Biol       Date:  1986-08       Impact factor: 4.272

Review 3.  Cellular aging--clonal senescence. A review (Part I).

Authors:  G M Martin
Journal:  Am J Pathol       Date:  1977-11       Impact factor: 4.307

Review 4.  Human replicative senescence. A molecular study.

Authors:  P J Hensler; O M Pereira-Smith
Journal:  Am J Pathol       Date:  1995-07       Impact factor: 4.307

5.  Quiescent human diploid cells can inhibit entry into S phase in replicative nuclei in heterodikaryons.

Authors:  G H Stein; R M Yanishevsky
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

Review 6.  Werner's syndrome: a review of recent research with an analysis of connective tissue metabolism, growth control of cultured cells, and chromosomal aberrations.

Authors:  D Salk
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

Review 7.  Cell culture aging.

Authors:  M Reff; E L Schneider
Journal:  Mol Cell Biochem       Date:  1981-05-26       Impact factor: 3.396

8.  Carcinogen-transformed human cells are inhibited from entry into S phase by fusion to senescent cells but cells transformed by DNA tumor viruses overcome the inhibition.

Authors:  G H Stein; R M Yanishevsky; L Gordon; M Beeson
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

9.  Induction of cellular deoxyribonucleic acid synthesis in butyrate-treated cells by simian virus 40 deoxyribonucleic acid.

Authors:  S Kawasaki; L Diamond; R Baserga
Journal:  Mol Cell Biol       Date:  1981-11       Impact factor: 4.272

10.  Specific growth inhibitory sequences in genomic DNA from quiescent human embryo fibroblasts.

Authors:  R Padmanabhan; T H Howard; B H Howard
Journal:  Mol Cell Biol       Date:  1987-05       Impact factor: 4.272
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.