| Literature DB >> 11504889 |
A Csáki1, R Möller, W Straube, J M Köhler, W Fritzsche.
Abstract
Monolayers of single-stranded DNA on gold substrates were studied by scanning force microscopy. Complementary DNA probes labeled by gold nanoparticles were applied for contrast enhancement. Substrate regions modified with DNA could be visualized in a highly specific manner. The influence of the solution concentration on the surface density of adsorbed nanoparticles could be visualized. Because individual label particles can be easily detected, this labeling technique opens the way for characterization of DNA monolayers with a lateral resolution in the nanometer range.Mesh:
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Year: 2001 PMID: 11504889 PMCID: PMC55865 DOI: 10.1093/nar/29.16.e81
Source DB: PubMed Journal: Nucleic Acids Res ISSN: 0305-1048 Impact factor: 16.971