Literature DB >> 24092

Salicylic acid fails to inhibit generation of thromboxane A2 activity in platelets after in vivo administration to the rat.

B B Vargaftig.   

Abstract

Arachidonic acid-induced aggregation of rat platelets and the accompanying generation of thromboxane A2 activity were inhibited by aspirin, whereas 20 times higher doses of salicylic, gentisic and salicyluric acids were inactive. Salicylic acid administered to the rats before aspirin prevented the inhibition of the cyclo-oxygenase-mediated effects of arachidonic acid. These results do not support the hypothesis that the anti-inflammatory activity of salicylic acid is due to inhibition of prostaglandin systhetase (cyclo-oxygenase) by an unknown metabolite and indicate that salicylic acid displays an anti-inflammatory activity independent inhibition of prostaglandin biosynthesis.

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Year:  1978        PMID： 24092     DOI： 10.1111/j.2042-7158.1978.tb13171.x

Source DB:  PubMed          Journal:  J Pharm Pharmacol        ISSN： 0022-3573            Impact factor:   3.765


  13 in total

1.  Effects of salicylic and acetylsalicylic acid alone and in combination on platelet aggregation and prostanoid synthesis in man.

Authors:  B Rosenkranz; C Fischer; C O Meese; J C Frölich
Journal:  Br J Clin Pharmacol       Date:  1986-03       Impact factor: 4.335

Review 2.  New insights into the mode of action of anti-inflammatory drugs.

Authors:  J R Vane; R M Botting
Journal:  Inflamm Res       Date:  1995-01       Impact factor: 4.575

Review 3.  Aspirin and prostaglandins: some recent developments.

Authors:  M J Smith
Journal:  Agents Actions       Date:  1978-06

4.  Aspirin, salicylate and prostaglandins.

Authors:  M J Smith; A W Ford-Hutchinson; J R Walker; J A Slack
Journal:  Agents Actions       Date:  1979-12

5.  [Effects of acetylsalicylic acid on partial functions of human thrombocytes are not inhibited in vivo by salicylic acid].

Authors:  R Simrock; V Lischke; A Missalla; P Schwidtal; H K Breddin
Journal:  Klin Wochenschr       Date:  1984-03-01

6.  The evolution of non-steroidal anti-inflammatory drugs and their mechanisms of action.

Authors:  J Vane
Journal:  Drugs       Date:  1987       Impact factor: 9.546

7.  Effect of acetylsalicylic acid on plasma thromboxane B2 and platelet aggregation in man.

Authors:  E Nuotto; A Gordin; M K Paasonen; T Metsä-Ketelä; U Lamminsivu
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

8.  Arachidonate metabolism via lipoxygenase and 12L-hydroperoxy-5,8,10,14-icosatetraenoic acid peroxidase sensitive to anti-inflammatory drugs.

Authors:  M I Siegel; R T McConnell; N A Porter; P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1980-01       Impact factor: 11.205

9.  Effects of inflammatory agents on endothelial lysosomal fragility and their inhibition by anti-inflammatory drugs.

Authors:  J R Yoffe
Journal:  Br J Pharmacol       Date:  1981-04       Impact factor: 8.739

10.  Bioavailability of acetylsalicylic acid and salicylic acid from rapid-and slow-release formulations, and in combination with dipyridamol.

Authors:  B Brantmark; E Wåhlin-Boll; A Melander
Journal:  Eur J Clin Pharmacol       Date:  1982       Impact factor: 2.953
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