Literature DB >> 11470606

Microtubule-stabilizing agents: a growing class of important anticancer drugs.

K H Altmann1.   

Abstract

Microtubule-stabilizing agents continue to play an important role in anticancer drug discovery and development. New agents were again discovered in the past year, including small synthetic molecules. At least three new taxanes and two compounds of the epothilone class of natural products underwent clinical trials in 2000. Unexpected new findings about synergistic effects between different microtubule-stabilizing agents in vitro raise new prospects for combination chemotherapy.

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Year:  2001        PMID： 11470606     DOI： 10.1016/s1367-5931(00)00225-8

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  21 in total

1.  Development of a mariner-based transposon for use in Sorangium cellulosum.

Authors:  Bryan Julien; Ruby Fehd
Journal:  Appl Environ Microbiol       Date:  2003-10       Impact factor: 4.792

Review 2.  Drug discovery targeting cell division proteins, microtubules and FtsZ.

Authors:  Iwao Ojima; Kunal Kumar; Divya Awasthi; Jacob G Vineberg
Journal:  Bioorg Med Chem       Date:  2014-03-05       Impact factor: 3.641

Review 3.  Recent advances in combretastatin based derivatives and prodrugs as antimitotic agents.

Authors:  Zaki S Seddigi; M Shaheer Malik; A Prasanth Saraswati; Saleh A Ahmed; Ahmed O Babalghith; Hawazen A Lamfon; Ahmed Kamal
Journal:  Medchemcomm       Date:  2017-07-04       Impact factor: 3.597

4.  First report of anti-Trichomonas vaginalis activity of the medicinal plant Polygala decumbens from the Brazilian semi-arid region, Caatinga.

Authors:  Amanda Piccoli Frasson; Odelta dos Santos; Mariana Duarte; Danielle da Silva Trentin; Raquel Brandt Giordani; Alexandre Gomes da Silva; Márcia Vanusa da Silva; Tiana Tasca; Alexandre José Macedo
Journal:  Parasitol Res       Date:  2011-12-29       Impact factor: 2.289

Review 5.  Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease.

Authors:  Kurt R Brunden; John Q Trojanowski; Amos B Smith; Virginia M-Y Lee; Carlo Ballatore
Journal:  Bioorg Med Chem       Date:  2013-12-30       Impact factor: 3.641

Review 6.  Targeting microtubules by natural agents for cancer therapy.

Authors:  Eiman Mukhtar; Vaqar Mustafa Adhami; Hasan Mukhtar
Journal:  Mol Cancer Ther       Date:  2014-01-16       Impact factor: 6.261

7.  The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.

Authors:  Xin Zhang; Sudhir Raghavan; Michael Ihnat; Jessica E Thorpe; Bryan C Disch; Anja Bastian; Lora C Bailey-Downs; Nicholas F Dybdal-Hargreaves; Cristina C Rohena; Ernest Hamel; Susan L Mooberry; Aleem Gangjee
Journal:  Bioorg Med Chem       Date:  2014-05-14       Impact factor: 3.641

8.  Fusarisetins: Structure-function studies on a novel class of cell migration inhibitors.

Authors:  Eduardo J E Caro-Diaz; Aereas Aung; Jing Xu; Shyni Varghese; Emmanuel A Theodorakis
Journal:  Org Chem Front       Date:  2014-04-01       Impact factor: 5.281

Review 9.  Recent contributions of structure-based drug design to the development of antibacterial compounds.

Authors:  Bart L Staker; Garry W Buchko; Peter J Myler
Journal:  Curr Opin Microbiol       Date:  2015-10       Impact factor: 7.934

10.  Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.

Authors:  Ravi Kumar Vyas Devambatla; Ojas A Namjoshi; Shruti Choudhary; Ernest Hamel; Corena V Shaffer; Cristina C Rohena; Susan L Mooberry; Aleem Gangjee
Journal:  J Med Chem       Date:  2016-06-07       Impact factor: 7.446
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