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Literature DB >> 24910777

Fusarisetins: Structure-function studies on a novel class of cell migration inhibitors.

Eduardo J E Caro-Diaz, Aereas Aung, Jing Xu, Shyni Varghese, Emmanuel A Theodorakis.

Abstract

Herein, we report the effects of fusarisetin A on cell morphology focusing in particular on actin and microtubules dynamics. We also report the synthesis and structure-function studies of a designed library of synthetic fusarisetins in cell-based assays.

Entities: CellLine Chemical Disease Gene Species

Year: 2014 PMID： 24910777 PMCID： PMC4043345 DOI： 10.1039/C3QO00067B

Source DB: PubMed Journal: Org Chem Front ISSN： 2052-4110 Impact factor: 5.281

50 in total

1. Novel actin depolymerizing macrolide aplyronine A.

Authors: S Saito; S Watabe; H Ozaki; H Kigoshi; K Yamada; N Fusetani; H Karaki
Journal: J Biochem Date: 1996-09 Impact factor: 3.387

Review 2. A perspective on cancer cell metastasis.

Authors: Christine L Chaffer; Robert A Weinberg
Journal: Science Date: 2011-03-25 Impact factor: 47.728

3. Actin polymerization. The mechanism of action of cytochalasin D.

Authors: D W Goddette; C Frieden
Journal: J Biol Chem Date: 1986-12-05 Impact factor: 5.157

4. Fusarisetin A, an acinar morphogenesis inhibitor from a soil fungus, Fusarium sp. FN080326.

Authors: Jae-Hyuk Jang; Yukihiro Asami; Jun-Pil Jang; Sun-Ok Kim; Dong Oh Moon; Kee-Sun Shin; Daisuke Hashizume; Makoto Muroi; Tamio Saito; Hyuncheol Oh; Bo Yeon Kim; Hiroyuki Osada; Jong Seog Ahn
Journal: J Am Chem Soc Date: 2011-04-18 Impact factor: 15.419

Review 5. Cancer metastasis therapeutic targets and drug discovery: emerging small-molecule protein kinase inhibitors.

Authors: Tomi K Sawyer
Journal: Expert Opin Investig Drugs Date: 2004-01 Impact factor: 6.206

Review 6. Molecular basis of metastasis.

Authors: Anne C Chiang; Joan Massagué
Journal: N Engl J Med Date: 2008-12-25 Impact factor: 91.245

Fusarisetins: Structure-function studies on a novel class of cell migration inhibitors.

1. Novel actin depolymerizing macrolide aplyronine A.

Review 2. A perspective on cancer cell metastasis.

3. Actin polymerization. The mechanism of action of cytochalasin D.

4. Fusarisetin A, an acinar morphogenesis inhibitor from a soil fungus, Fusarium sp. FN080326.

Review 5. Cancer metastasis therapeutic targets and drug discovery: emerging small-molecule protein kinase inhibitors.

Review 6. Molecular basis of metastasis.

7. Inhibition of tumor metastasis by a growth factor receptor bound protein 2 Src homology 2 domain-binding antagonist.

8. Indirubin derivative 6BIO suppresses metastasis.

Review 9. Dissemination and growth of cancer cells in metastatic sites.

10. Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines.

1. Synthetic Strategies Toward the Decalin Motif of Maklamicin and Related Spirotetronates.

Review 2. The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms.