Literature DB >> 11462986

Calculation of the hydrophobicity of platinum drugs.

J A Platts1, D E Hibbs, T W Hambley, M D Hall.   

Abstract

Models of the hydrophobicity of platinum drugs based on exposed surface areas of polar and nonpolar atoms are presented. For a total of 24 log P(oct) data, the best model resulted in a standard deviation of 0.35 over a range of more than 4 log units, with regression coefficients in broad agreement with previous models of log P(oct) for organic molecules. This model is used to compare log P(oct) to cell uptake for five platinum drugs and hence to establish an exponential relation between these parameters.

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Year:  2001        PMID： 11462986     DOI： 10.1021/jm001080k

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  11 in total

1.  The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells.

Authors:  Matthew D Hall; Carolyn T Dillon; Mei Zhang; Philip Beale; Zhonghou Cai; Barry Lai; Anton P J Stampfl; Trevor W Hambley
Journal:  J Biol Inorg Chem       Date:  2003-07-12       Impact factor: 3.358

2.  Antiproliferative Pt(IV) complexes: synthesis, biological activity, and quantitative structure-activity relationship modeling.

Authors:  Paola Gramatica; Ester Papa; Mara Luini; Elena Monti; Marzia B Gariboldi; Mauro Ravera; Elisabetta Gabano; Luca Gaviglio; Domenico Osella
Journal:  J Biol Inorg Chem       Date:  2010-06-06       Impact factor: 3.358

3.  Molecular and statistical modeling of reduction peak potential and lipophilicity of platinum(IV) complexes.

Authors:  James A Platts; Giuseppe Ermondi; Giulia Caron; Mauro Ravera; Elisabetta Gabano; Luca Gaviglio; Giorgio Pelosi; Domenico Osella
Journal:  J Biol Inorg Chem       Date:  2010-11-16       Impact factor: 3.358

4.  DFT-based QSAR and QSPR models of several cis-platinum complexes: solvent effect.

Authors:  Pubalee Sarmah; Ramesh C Deka
Journal:  J Comput Aided Mol Des       Date:  2009-03-24       Impact factor: 3.686

5.  Synthesis, characterization, and cytotoxicity of platinum(IV) carbamate complexes.

Authors:  Justin J Wilson; Stephen J Lippard
Journal:  Inorg Chem       Date:  2011-03-01       Impact factor: 5.165

6.  Study of the synthesis, antiproliferative properties, and interaction with DNA and polynucleotides of cisplatin-like Pt(II) complexes containing carcinogenic polyaromatic amines.

Authors:  Elisabetta Gabano; Sofia Gama; Filipa Mendes; Marzia B Gariboldi; Elena Monti; Sophie Bombard; Sabrina Bianco; Mauro Ravera
Journal:  J Biol Inorg Chem       Date:  2013-07-20       Impact factor: 3.358

7.  Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles.

Authors:  Khine Myint; Yan Li; James Paxton; Mark McKeage
Journal:  PLoS One       Date:  2015-07-01       Impact factor: 3.240

8.  Studies on log Po/w of quinoxaline di-N-oxides: a comparison of RP-HPLC experimental and predictive approaches.

Authors:  Elsa Moreno; Elisabetta Gabano; Enrique Torres; James A Platts; Mauro Ravera; Ignacio Aldana; Antonio Monge; Silvia Pérez-Silanes
Journal:  Molecules       Date:  2011-09-13       Impact factor: 4.411

9.  Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer.

Authors:  Khine Myint; Riya Biswas; Yan Li; Nancy Jong; Stephen Jamieson; Johnson Liu; Catherine Han; Christopher Squire; Fabrice Merien; Jun Lu; Takeo Nakanishi; Ikumi Tamai; Mark McKeage
Journal:  Sci Rep       Date:  2019-02-19       Impact factor: 4.379

10.  Lipophilicity assessment of ruthenium(II)-arene complexes by the means of reversed-phase thin-layer chromatography and DFT calculations.

Authors:  Khalil Salem A M Shweshein; Filip Andrić; Aleksandra Radoičić; Matija Zlatar; Maja Gruden-Pavlović; Zivoslav Tešić; Dušanka Milojković-Opsenica
Journal:  ScientificWorldJournal       Date:  2014-01-22
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