| Literature DB >> 11456567 |
S J Duncan1, S Grüschow, D H Williams, C McNicholas, R Purewal, M Hajek, M Gerlitz, S Martin, S K Wrigley, M Moore.
Abstract
Wild-type p53 plays a crucial role in the prevention of cancer. Since dysfunction of p53 can be caused by increased levels of the protein MDM2, small molecules which antagonize the interaction between these two proteins have potential in cancer therapy. The discovery and structure determination of a fungal metabolite, chlorofusin, which antagonizes the p53/MDM2 interaction are reported.Entities:
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Year: 2001 PMID： 11456567 DOI： 10.1021/ja002940p
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419