Literature DB >> 11430046

Candelalides A-C: novel diterpenoid pyrones from fermentations of Sesquicillium candelabrum as blockers of the voltage-gated potassium channel Kv1.3.

S B Singh1, D L Zink, A W Dombrowski, G Dezeny, G F Bills, J P Felix, R S Slaughter, M A Goetz.   

Abstract

[figure: see text] Blockers of the voltage-gated potassium channel Kv1.3 are potential immunosuppressants. Candelalides A-C are three novel diterpenoid pyrones that block this channel. The structure, stereochemistry, and activity against Kv1.3 are described.

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Year:  2001        PMID： 11430046     DOI： 10.1021/ol006891x

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  State-dependent blocking mechanism of Kv 1.3 channels by the antimycobacterial drug clofazimine.

Authors:  Malika Faouzi; John Starkus; Reinhold Penner
Journal:  Br J Pharmacol       Date:  2015-10-09       Impact factor: 8.739

Review 2.  K+ channel modulators for the treatment of neurological disorders and autoimmune diseases.

Authors:  Heike Wulff; Boris S Zhorov
Journal:  Chem Rev       Date:  2008-05       Impact factor: 60.622

3.  Synthesis and SAR of Lehualide B: a marine-derived natural product with potent anti-multiple myeloma activity.

Authors:  Valer Jeso; Chunying Yang; Michael D Cameron; John L Cleveland; Glenn C Micalizio
Journal:  ACS Chem Biol       Date:  2013-04-02       Impact factor: 5.100

4.  Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases.

Authors:  Christine Beeton; Michael W Pennington; Heike Wulff; Satendra Singh; Daniel Nugent; George Crossley; Ilya Khaytin; Peter A Calabresi; Chao-Yin Chen; George A Gutman; K George Chandy
Journal:  Mol Pharmacol       Date:  2005-01-21       Impact factor: 4.436

5.  Synthetic efforts towards the stereoselective synthesis of NF00659B1.

Authors:  Do-Yeon Kwon; Kiyoun Lee; Hyeri Park; Mi Jung Kim; Jiyong Hong
Journal:  Bioorg Med Chem Lett       Date:  2018-02-19       Impact factor: 2.823

6.  Structure and biosynthesis of sorangipyranone - a new γ-dihydropyrone from the myxobacterial strain MSr12020.

Authors:  Dorothy A Okoth; Joachim J Hug; Attila Mándi; Tibor Kurtán; Ronald Garcia; Rolf Müller
Journal:  J Ind Microbiol Biotechnol       Date:  2021-06-04       Impact factor: 4.258

7.  Identification and enhancing production of a novel macrolide compound in engineered Streptomyces peucetius.

Authors:  Van Thuy Thi Pham; Hue Thi Nguyen; Chung Thanh Nguyen; Ye Seul Choi; Dipesh Dhakal; Tae-Su Kim; Hye Jin Jung; Tokutaro Yamaguchi; Jae Kyung Sohng
Journal:  RSC Adv       Date:  2021-01-14       Impact factor: 3.361
  7 in total

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