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Literature DB >> 11412964

Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase.

Abstract

Incubation of chirally deuterated NADPH with 6-deoxyerythronolide B synthase (DEBS) modules 5 and module 6 and analysis of the derived triketide lactones established that the two ketoreductase domains, KR5 and KR6, are both specific for the 4-pro-S hydride of the nicotinamide cofactor.

Entities: Chemical

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Year: 2001 PMID： 11412964 DOI： 10.1016/s0960-894x(00)00529-1

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

11 in total

Review 1. Programming of erythromycin biosynthesis by a modular polyketide synthase.

Authors: David E Cane
Journal: J Biol Chem Date: 2010-06-03 Impact factor: 5.157

Review 2. Biosynthesis of depsipeptides, or Depsi: The peptides with varied generations.

Authors: Diego A Alonzo; T Martin Schmeing
Journal: Protein Sci Date: 2020-11-02 Impact factor: 6.725

3. Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase.

Authors: Jiaquan Wu; Toby J Zaleski; Chiara Valenzano; Chaitan Khosla; David E Cane
Journal: J Am Chem Soc Date: 2005-12-14 Impact factor: 15.419

4. Structural and stereochemical analysis of a modular polyketide synthase ketoreductase domain required for the generation of a cis-alkene.

Authors: Shilah A Bonnett; Jonathan R Whicher; Kancharla Papireddy; Galina Florova; Janet L Smith; Kevin A Reynolds
Journal: Chem Biol Date: 2013-06-20

10. Structural insight into the tetramerization of an iterative ketoreductase siam through aromatic residues in the interfaces.

Authors: Hua Wang; Huaidong Zhang; Yi Zou; Yanling Mi; Shuangjun Lin; Zhixiong Xie; Yunjun Yan; Houjin Zhang
Journal: PLoS One Date: 2014-06-05 Impact factor: 3.240

Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase.

Review 1. Programming of erythromycin biosynthesis by a modular polyketide synthase.

Review 2. Biosynthesis of depsipeptides, or Depsi: The peptides with varied generations.

3. Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase.

4. Structural and stereochemical analysis of a modular polyketide synthase ketoreductase domain required for the generation of a cis-alkene.

5. Structural and biochemical analyses of regio- and stereospecificities observed in a type II polyketide ketoreductase.

Review 6. Structural analysis of protein-protein interactions in type I polyketide synthases.

7. The biochemical basis for stereochemical control in polyketide biosynthesis.

8. Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase.

Review 9. Dissecting complex polyketide biosynthesis.

10. Structural insight into the tetramerization of an iterative ketoreductase siam through aromatic residues in the interfaces.