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Literature DB >> 11407594

The INK4A/ARF locus: role in cell cycle control and apoptosis and implications for glioma growth.

S M Ivanchuk¹, S Mondal, P B Dirks, J T Rutka.

Abstract

The unique INK4A/ARF locus at chromosome 9p21 encodes two distinct proteins that intimately link the pRB and p53 tumour suppressor pathways. p16INK4A has been identified as an inhibitor of the cell cycle, capable of inducing arrest in G1 phase. p14/p19ARF on the other hand can induce both G1 and G2 arrest due to its stabilizing effects on the p53 transcription factor. In addition to their roles in growth arrest, both proteins are involved in cellular senescence and apoptosis. The frequent mutation or deletion of INK4A/ARF in human tumours as well as the occurence of tumours in the murine knockout models have identified both p16 and ARF as bona fide tumour suppressors.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2001 PMID： 11407594 DOI： 10.1023/a:1010632309113

Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130

70 in total

1. INK4d-deficient mice are fertile despite testicular atrophy.

Authors: F Zindy; J van Deursen; G Grosveld; C J Sherr; M F Roussel
Journal: Mol Cell Biol Date: 2000-01 Impact factor: 4.272

2. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

Authors: M Serrano; A W Lin; M E McCurrach; D Beach; S W Lowe
Journal: Cell Date: 1997-03-07 Impact factor: 41.582

3. Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein.

Authors: M Kim; Y Katayose; L Rojanala; S Shah; M Sgagias; L Jang; Y J Jung; S H Lee; S G Hwang; K H Cowan
Journal: Cell Death Differ Date: 2000-08 Impact factor: 15.828

4. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

Authors: F Zindy; D E Quelle; M F Roussel; C J Sherr
Journal: Oncogene Date: 1997-07-10 Impact factor: 9.867

5. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

Authors: F J Stott; S Bates; M C James; B B McConnell; M Starborg; S Brookes; I Palmero; K Ryan; E Hara; K H Vousden; G Peters
Journal: EMBO J Date: 1998-09-01 Impact factor: 11.598

6. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.

Authors: D E Quelle; F Zindy; R A Ashmun; C J Sherr
Journal: Cell Date: 1995-12-15 Impact factor: 41.582

7. Regulation of cyclin dependent kinase inhibitor proteins during neonatal cerebella development.

Authors: G Watanabe; P Pena; G E Shambaugh; G K Haines; R G Pestell
Journal: Brain Res Dev Brain Res Date: 1998-06-15

8. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice.

Authors: E C Holland; W P Hively; R A DePinho; H E Varmus
Journal: Genes Dev Date: 1998-12-01 Impact factor: 11.361

9. Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4.

Authors: I J Byeon; J Li; K Ericson; T L Selby; A Tevelev; H J Kim; P O'Maille; M D Tsai
Journal: Mol Cell Date: 1998-02 Impact factor: 17.970

10. Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.

Authors: D Parry; S Bates; D J Mann; G Peters
Journal: EMBO J Date: 1995-02-01 Impact factor: 11.598

28 in total

1. Genomic aberrations in pediatric diffuse intrinsic pontine gliomas.

Authors: Katherine E Warren; Keith Killian; Miia Suuriniemi; Yonghong Wang; Martha Quezado; Paul S Meltzer
Journal: Neuro Oncol Date: 2011-11-07 Impact factor: 12.300

2. Ink4a/Arf loss promotes tumor recurrence following Ras inhibition.

Authors: Matthew W Vanbrocklin; James P Robinson; Kristin J Lastwika; Andrea J McKinney; H Michael Gach; Sheri L Holmen
Journal: Neuro Oncol Date: 2011-10-20 Impact factor: 12.300

3. INK4a knockout mice exhibit increased fibrosis under normal conditions and in response to unilateral ureteral obstruction.

Authors: Jesse M Wolstein; David H Lee; Jennine Michaud; Venessa Buot; Beth Stefanchik; Matthew D Plotkin
Journal: Am J Physiol Renal Physiol Date: 2010-09-22

The INK4A/ARF locus: role in cell cycle control and apoptosis and implications for glioma growth.

1. INK4d-deficient mice are fertile despite testicular atrophy.

2. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

3. Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein.

4. Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

5. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

6. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.

7. Regulation of cyclin dependent kinase inhibitor proteins during neonatal cerebella development.

8. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice.

9. Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4.

10. Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.

1. Genomic aberrations in pediatric diffuse intrinsic pontine gliomas.

2. Ink4a/Arf loss promotes tumor recurrence following Ras inhibition.

3. INK4a knockout mice exhibit increased fibrosis under normal conditions and in response to unilateral ureteral obstruction.

4. Significance of MMP11 and P14(ARF) expressions in clinical outcomes of patients with laryngeal cancer.

5. Distinct patterns of gene expression induced by viral oncogenes in human embryonic brain cells.

Review 6. Vertebrate animal models of glioma: understanding the mechanisms and developing new therapies.

7. Comparison of the inhibitory effects of three transcriptional variants of CDKN2A in human lung cancer cell line A549.

8. Oxidative stress is linked to ERK1/2-p16 signaling-mediated growth defect in ATM-deficient astrocytes.

9. Immunohistochemical markers for prognosis of ependymal neoplasms.

Review 10. Immunological considerations of modern animal models of malignant primary brain tumors.