| Literature DB >> 11393722 |
M Nakamura1, K Hirade, T Sugiyama, Y Katagiri.
Abstract
A new method for measuring zonisamide (ZNS) in plasma by high-performance liquid chromatography was developed by using a 2-microm reversed-phase non-porous silica column. ZNS in plasma was first purified with a column extraction technique and injected onto the non-porous silica column. Calibration curve was linear over the concentration range of 1-80 microg/ml in plasma. The recoveries of ZNS added to plasma were more than 95.4% with the coefficient of variation less than 9.0%. We developed a rapid routine method using the non-porous silica column that was accurate and improved solvent consumption in the measurement of ZNS.Entities:
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Year: 2001 PMID： 11393722 DOI： 10.1016/s0378-4347(01)00062-7
Source DB: PubMed Journal: J Chromatogr B Biomed Sci Appl ISSN： 1387-2273