Literature DB >> 113803

Zimelidine: a therapeutic and pharmacokinetic study in depression.

A Coppen, V A Ramo Rao, C Swade, K Wood.   

Abstract

Zimelidine, a bicyclic compound with a strong effect on the neuronal reuptake of 5-hydroxy-tryptamine and with weak anticholinergic actions, was evaluated for its antidepressant efficacy in a double-blind comparative trial with amitriptyline. In doses of 200 mg a day it was found to be as effective as 150 mg amitriptyline, but with significantly less subjective side-effects. The plasma concentration of zimelidine and its metabolite, norzimelidine, showed no significant correlation with therapeutic outcome.

Entities:  

Mesh：

Substances：

Year:  1979        PMID： 113803     DOI： 10.1007/bf00433549

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  10 in total

1.  CLINICAL TRIAL OF THE TREATMENT OF DEPRESSIVE ILLNESS. REPORT TO THE MEDICAL RESEARCH COUNCIL BY ITS CLINICAL PSYCHIATRY COMMITTEE.

Authors:  M THIERY
Journal:  Br Med J       Date:  1965-04-03

2.  A rating scale for depression.

Authors:  M HAMILTON
Journal:  J Neurol Neurosurg Psychiatry       Date:  1960-02       Impact factor: 10.154

3.  (Z)-dimethylamino-1-(4-bromophenyl)-1-(3-pyridyl) propene (h 102/09), a new selective inhibitor of the neuronal 5-hydroxytryptamine uptake.

Authors:  S B Ross; S O Ogren; A L Renyi
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1976-08

4.  Lithium salts: therapeutic and unwanted effects.

Authors:  K Ghose
Journal:  Br J Hosp Med       Date:  1977-12

5.  Antidepressant evaluation and the pharmacological actions of FG4963 in depressive patients.

Authors:  K Ghose; R Gupta; A Coppen; J Lund
Journal:  Eur J Pharmacol       Date:  1977-03-07       Impact factor: 4.432

6.  Effect of zimelidine (H 102/09) in depressive patients.

Authors:  O Benkert; G Laakmann; L Ott; A Strauss; R Zimmer
Journal:  Arzneimittelforschung       Date:  1977

7.  Inhibition of the neuronal uptake of 5-hydroxytryptamine and noradrenaline in rat brain by (Z)- and (E)-3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridyl) allylamines and their secondary analogues.

Authors:  S B Ross; A L Renyi
Journal:  Neuropharmacology       Date:  1977-01       Impact factor: 5.250

8.  Initial clinical trial based on biochemical methodology of zimelidine (a serotonin uptake inhibitor) in depressed patients.

Authors:  B Siwers; V A Ringberger; J R Tuck; F Sjöqvist
Journal:  Clin Pharmacol Ther       Date:  1977-02       Impact factor: 6.875

9.  Platelet 5-hydroxytryptamine accumulation in depressive illness.

Authors:  A Coppen; C Swade; K Wood
Journal:  Clin Chim Acta       Date:  1978-07-01       Impact factor: 3.786

10.  Amitriptyline plasma-concentration and clinical effect. A World Health Organisation Collaborative Study.

Authors:  A Coppen; K Ghose; S Montgomery; V A Rama Rao; J Bailey; J Christiansen; P L Mikkleson; H M van Praag; F van de Poel; E J Minsker; V G Kozulja; N Matussek; G Kungkunz; A Jłrgensen
Journal:  Lancet       Date:  1978-01-14       Impact factor: 79.321
  10 in total
  31 in total

1.  In vivo electrochemical measurements of serotonin clearance in rat striatum: effects of neonatal 6-hydroxydopamine-induced serotonin hyperinnervation and serotonin uptake inhibitors.

Authors:  J Luthman; M N Friedemann; B J Hoffer; G A Gerhardt
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

2.  On central effects of serotonin re-uptake inhibitors: quantitative EEG and psychometric studies with sertraline and zimelidine.

Authors:  B Saletu; J Grünberger; L Linzmayer
Journal:  J Neural Transm       Date:  1986       Impact factor: 3.575

3.  Similar effect on REM sleep but differential effect on slow wave sleep of the two 5-HT uptake inhibitors zimeldine and alaproclate in cats and rats.

Authors:  L Sommerfelt; E R Hauge; R Ursin
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

4.  Effects of zimelidine on serotoninergic and noradrenergic neurons after repeated administration in the rat.

Authors:  S B Ross; H Hall; A L Renyi; D Westerlund
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

5.  Safety of zimeldine in overdose.

Authors:  F K Judd; T R Norman; G D Burrows
Journal:  Br Med J (Clin Res Ed)       Date:  1983-11-26

6.  Biochemical effects and drug levels in rats after long-term treatment with the specific 5-HT-uptake inhibitor, citalopram.

Authors:  J Hyttel; K F Overø; J Arnt
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

7.  Effects of the two antidepressant drugs mianserin and indalpine on the serotonergic system: single-cell studies in the rat.

Authors:  P Blier; C de Montigny; D Tardif
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

8.  Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems by antidepressant drugs.

Authors:  S O Ogren; K Fuxe; L F Agnati; J A Gustafsson; G Jonsson; A C Holm
Journal:  J Neural Transm       Date:  1979       Impact factor: 3.575

9.  Effects of zimeldine, mianserin and amitriptyline on psychomotor skills and their interaction with ethanol a placebo controlled cross-over study.

Authors:  T Seppälä; C Strömberg; I Bergman
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

10.  A study of the effects of zimelidine on the pharmacokinetics and pharmacodynamics of temazepam in healthy volunteers.

Authors:  D Fagan; D B Scott; B Tiplady
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.