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Literature DB >> 321228

Antidepressant evaluation and the pharmacological actions of FG4963 in depressive patients.

Abstract

FG4963 a phenylpiperidine derivative and potent 5-HT reuptake inhibitor at neuronal sites was investigated in a group of 10 depressive patients, and its effect was compared with that of amitryptyline in a group of 10 depressive patients treated with amitriptyline. FG4963 was found to be significantly inferior as an antidepressant compared to amitryptyline over a 6-week period. FG4963 did not appear to be anticholinergic as judged by its lack of effect on salivary flow. Its effect (in the dosage used) on the tyramine dose--pressor response and NA dose--pressor response tests were less than those of amitryptyline.

Entities: Chemical Disease Species

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Year: 1977 PMID： 321228 DOI： 10.1016/0014-2999(77)90187-x

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

13 in total

Review 1. Antidepressants and serotonergic neurotransmission: an integrative review.

Authors: P Willner
Journal: Psychopharmacology (Berl) Date: 1985 Impact factor: 4.530

2. Cardiovascular (ECG and systolic time intervals) and anticholinergic effects of repeated doses of femoxetine--a comparison with amitriptyline and placebo in healthy men.

Authors: S J Warrington; P Turner; B K Skrumsager
Journal: Br J Clin Pharmacol Date: 1989-03 Impact factor: 4.335

3. Assessment of Peripheral adrenergic activity and its interactions with drugs in man.

Authors: K Ghose
Journal: Eur J Clin Pharmacol Date: 1980-04 Impact factor: 2.953

4. A placebo controlled comparison of the effects of pirenzepine and amitriptyline on the tyramine pressor test in healthy volunteers.

Authors: M R Wilkins; R D Wynne; M J Kendall
Journal: Br J Clin Pharmacol Date: 1985-06 Impact factor: 4.335

5. Effect of chronic tricylic antidepressant treatment on the serotoninergic autoreceptor: a microiontophoretic study in the rat.

Authors: P Blier; C de Montigny
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1980-11 Impact factor: 3.000

Antidepressant evaluation and the pharmacological actions of FG4963 in depressive patients.

Review 1. Antidepressants and serotonergic neurotransmission: an integrative review.

2. Cardiovascular (ECG and systolic time intervals) and anticholinergic effects of repeated doses of femoxetine--a comparison with amitriptyline and placebo in healthy men.

3. Assessment of Peripheral adrenergic activity and its interactions with drugs in man.

4. A placebo controlled comparison of the effects of pirenzepine and amitriptyline on the tyramine pressor test in healthy volunteers.

5. Effect of chronic tricylic antidepressant treatment on the serotoninergic autoreceptor: a microiontophoretic study in the rat.

6. Antidepressant activity and pharmacological interactions of ciclazindol.

7. The central antiserotonergic action of mianserin.

8. Acute and subacute effects on psychomotor performance of femoxetine alone and with alcohol.

9. Decreased tyramine sensitivity after discontinuation of amitriptyline therapy. An index of pharmacodynamic half-life.

10. Noradrenaline, depressive illness, and the action of amitriptyline.