| Literature DB >> 11374948 |
H Duan1, Y Takaishi, H Momota, Y Ohmoto, T Taki, Y Jia, D Li.
Abstract
Nine new sesquiterpene pyridine alkaloids [wilfornines A (1), B (2), C (3), D (4), E (5), F (8), and G (9); wilfordinines I (6) and J (7)] and six known compounds (10-15) were isolated from a clinically used extract (T(II)) of Tripterygium wilfordii. The structures of 1-9 were elucidated by spectroscopic and chemical methods. The inhibitory effects on cytokine production of 1-3 and several related compounds were evaluated. Compounds 10 and 14 showed significant inhibitory effects on cytokine production.Entities:
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Year: 2001 PMID： 11374948 DOI： 10.1021/np000504a
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050