Literature DB >> 11357958

Parkinson's disease is not associated with the combined alpha-synuclein/apolipoprotein E susceptibility genotype.

N Khan1, E Graham, P Dixon, C Morris, A Mander, D Clayton, J Vaughan, N Quinn, A Lees, S Daniel, N Wood, R de Silva.   

Abstract

A recent study showed significant association of sporadic Parkinson's disease with a polymorphism within the alpha-synuclein gene and closely linked DNA markers on chromosome 4q and the APOE epsilon4 allele. A combined alpha-synuclein/APOE-epsilon4 genotype increased the relative risk of developing Parkinson's disease 12-fold. We failed to confirm this association in a much larger sample of histopathologically proven cases of Parkinson's disease and controls.

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Year:  2001        PMID： 11357958

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  12 in total

Review 1.  The genetic basis of Parkinson's disease.

Authors:  T Foltynie; S Sawcer; C Brayne; R A Barker
Journal:  J Neurol Neurosurg Psychiatry       Date:  2002-10       Impact factor: 10.154

Review 2.  Neurodegenerative disorders: Parkinson's disease and Huntington's disease.

Authors:  S M Hague; S Klaffke; O Bandmann
Journal:  J Neurol Neurosurg Psychiatry       Date:  2005-08       Impact factor: 10.154

Review 3.  Deregulation of α-synuclein in Parkinson's disease: Insight from epigenetic structure and transcriptional regulation of SNCA.

Authors:  Subhrangshu Guhathakurta; Eugene Bok; Baggio A Evangelista; Yoon-Seong Kim
Journal:  Prog Neurobiol       Date:  2017-04-23       Impact factor: 11.685

Review 4.  Genetic variability in SNCA and Parkinson's disease.

Authors:  Lasse Pihlstrøm; Mathias Toft
Journal:  Neurogenetics       Date:  2011-07-29       Impact factor: 2.660

5.  alpha-Synuclein promoter RsaI T-to-C polymorphism and the risk of Parkinson's disease.

Authors:  C K Wang; C M Chen; C Y Chang; K H Chang; I C Chen; M L Li; G-J Lee-Chen; Y R Wu
Journal:  J Neural Transm (Vienna)       Date:  2006-04-11       Impact factor: 3.575

6.  Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene.

Authors:  Ornit Chiba-Falek; Jeffrey A Kowalak; Mark E Smulson; Robert L Nussbaum
Journal:  Am J Hum Genet       Date:  2005-01-25       Impact factor: 11.025

7.  Genome-wide association study confirms extant PD risk loci among the Dutch.

Authors:  Javier Simón-Sánchez; Jacobus J van Hilten; Bart van de Warrenburg; Bart Post; Henk W Berendse; Sampath Arepalli; Dena G Hernandez; Rob M A de Bie; Daan Velseboer; Hans Scheffer; Bas Bloem; Karin D van Dijk; Fernando Rivadeneira; Albert Hofman; André G Uitterlinden; Patrizia Rizzu; Zoltan Bochdanovits; Andrew B Singleton; Peter Heutink
Journal:  Eur J Hum Genet       Date:  2011-01-19       Impact factor: 4.246

8.  Age at onset in two common neurodegenerative diseases is genetically controlled.

Authors:  Yi-Ju Li; William K Scott; Dale J Hedges; Fengyu Zhang; P Craig Gaskell; Martha A Nance; Ray L Watts; Jean P Hubble; William C Koller; Rajesh Pahwa; Matthew B Stern; Bradley C Hiner; Joseph Jankovic; Fred A Allen; Christopher G Goetz; Frank Mastaglia; Jeffrey M Stajich; Rachel A Gibson; Lefkos T Middleton; Ann M Saunders; Burton L Scott; Gary W Small; Kristin K Nicodemus; Allison D Reed; Donald E Schmechel; Kathleen A Welsh-Bohmer; P Michael Conneally; Allen D Roses; John R Gilbert; Jeffery M Vance; Jonathan L Haines; Margaret A Pericak-Vance
Journal:  Am J Hum Genet       Date:  2002-03-01       Impact factor: 11.025

Review 9.  PARkinson's: From cellular mechanisms to potential therapeutics.

Authors:  Zsofia Lengyel-Zhand; Laura N Puentes; Robert H Mach
Journal:  Pharmacol Ther       Date:  2021-08-12       Impact factor: 12.310

Review 10.  Genetic susceptibility in Parkinson's disease.

Authors:  Jose Miguel Bras; Andrew Singleton
Journal:  Biochim Biophys Acta       Date:  2008-11-20
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