| Literature DB >> 11875758 |
Yi-Ju Li1, William K Scott, Dale J Hedges, Fengyu Zhang, P Craig Gaskell, Martha A Nance, Ray L Watts, Jean P Hubble, William C Koller, Rajesh Pahwa, Matthew B Stern, Bradley C Hiner, Joseph Jankovic, Fred A Allen, Christopher G Goetz, Frank Mastaglia, Jeffrey M Stajich, Rachel A Gibson, Lefkos T Middleton, Ann M Saunders, Burton L Scott, Gary W Small, Kristin K Nicodemus, Allison D Reed, Donald E Schmechel, Kathleen A Welsh-Bohmer, P Michael Conneally, Allen D Roses, John R Gilbert, Jeffery M Vance, Jonathan L Haines, Margaret A Pericak-Vance.
Abstract
To identify genes influencing age at onset (AAO) in two common neurodegenerative diseases, a genomic screen was performed for AAO in families with Alzheimer disease (AD; n=449) and Parkinson disease (PD; n=174). Heritabilities between 40%--60% were found in both the AD and PD data sets. For PD, significant evidence for linkage to AAO was found on chromosome 1p (LOD = 3.41). For AD, the AAO effect of APOE (LOD = 3.28) was confirmed. In addition, evidence for AAO linkage on chromosomes 6 and 10 was identified independently in both the AD and PD data sets. Subsequent unified analyses of these regions identified a single peak on chromosome 10q between D10S1239 and D10S1237, with a maximum LOD score of 2.62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases.Entities:
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Year: 2002 PMID： 11875758 PMCID： PMC379130 DOI： 10.1086/339815
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025