Recent developments in ectoparasiticides.

The sales and use of ectoparasiticides for the control of arthropod parasites of domestic animals constitute a major sector of the global animal health market. Animals are infected by a number of parasitic insect and acarine species causing major economic losses in production livestock, intense irritation and skin disease in companion animals, or public health issues, including bites of humans or zoonotic disease transmission. Dog and cat fleas, for example, can be a serious source of both animal and human irritation, which has led to a rapid expansion in the development of flea control products. The control of ectoparasite infections of veterinary importance still relies heavily on the use of chemicals that target the arthropod nervous system. Such compounds have suffered from a number of drawbacks, including the development of resistance and concerns over human and environmental safety. The search for safer technologies has, however, been hindered by the limited number of active target sites present in arthropods and, to some degree, by the ever-increasing costs of research and development of compounds with novel modes of action.This review provides a background to the currently available groups of ectoparasiticide compounds used in veterinary medicine and highlights some of the more recent developments including the introduction of insect growth regulators and new and improved methods of product application. Copyright 2001 Harcourt Publishers Ltd.