Literature DB >> 11349089

Pyrogenicity and cytokine-inducing properties of Streptococcus pyogenes superantigens: comparative study of streptococcal mitogenic exotoxin Z and pyrogenic exotoxin A.

H Müller-Alouf1, T Proft, T M Zollner, D Gerlach, E Champagne, P Desreumaux, C Fitting, C Geoffroy-Fauvet, J E Alouf, J M Cavaillon.   

Abstract

Streptococcal mitogenic exotoxin Z (SMEZ), a superantigen derived from Streptococcus pyogenes, provoked expansion of human lymphocytes expressing the Vbeta 2, 4, 7 and 8 motifs of T-cell receptor. SMEZ was pyrogenic in rabbits and stimulated the expression of the T-cell activation markers CD69 and cutaneous lymphocyte-associated antigen. A variety of cytokines was released by human mononuclear leukocytes stimulated with SMEZ, which was 10-fold more active than streptococcal pyrogenic exotoxin A. Th2-derived cytokines were elicited only by superantigens and not by streptococcal cells.

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Year:  2001        PMID： 11349089      PMCID： PMC98482          DOI： 10.1128/IAI.69.6.4141-4145.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  46 in total

1.  Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: clonal diversity and pyrogenic exotoxin expression.

Authors:  J M Musser; A R Hauser; M H Kim; P M Schlievert; K Nelson; R K Selander
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-01       Impact factor: 11.205

2.  "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A.

Authors:  W N Burnette
Journal:  Anal Biochem       Date:  1981-04       Impact factor: 3.365

3.  Purification and characterization of erythrogenic toxins. II. Communication: in vivo biological activities of erythrogenic toxin produced by streptococcus pyogenes strain ny-5.

Authors:  V Hríbalová; H Knöll; D Gerlach; W Köhler
Journal:  Zentralbl Bakteriol A       Date:  1980

4.  Bacterial superantigen-induced human lymphocyte responses are nitric oxide dependent and mediated by IL-12 and IFN-gamma.

Authors:  S Sriskandan; T J Evans; J Cohen
Journal:  J Immunol       Date:  1996-04-01       Impact factor: 5.422

5.  Polymyxin-B inhibition of LPS-induced interleukin-1 secretion by human monocytes is dependent upon the LPS origin.

Authors:  J M Cavaillon; N Haeffner-Cavaillon
Journal:  Mol Immunol       Date:  1986-09       Impact factor: 4.407

6.  Dysregulation of in vitro cytokine production by monocytes during sepsis.

Authors:  C Munoz; J Carlet; C Fitting; B Misset; J P Blériot; J M Cavaillon
Journal:  J Clin Invest       Date:  1991-11       Impact factor: 14.808

7.  Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production.

Authors:  D J Fast; P M Schlievert; R D Nelson
Journal:  Infect Immun       Date:  1989-01       Impact factor: 3.441

8.  Purification and characterization of Streptococcus pyogenes erythrogenic toxin type A produced by a cloned gene in Streptococcus sanguis.

Authors:  D Gerlach; W Köhler; H Knöll; L Moravek; C R Weeks; J J Ferretti
Journal:  Zentralbl Bakteriol Mikrobiol Hyg A       Date:  1987-10

9.  Severe group A streptococcal infections associated with a toxic shock-like syndrome and scarlet fever toxin A.

Authors:  D L Stevens; M H Tanner; J Winship; R Swarts; K M Ries; P M Schlievert; E Kaplan
Journal:  N Engl J Med       Date:  1989-07-06       Impact factor: 91.245

10.  The streptococcal superantigen SMEZ exhibits wide allelic variation, mosaic structure, and significant antigenic variation.

Authors:  T Proft; S L Moffatt; K D Weller; A Paterson; D Martin; J D Fraser
Journal:  J Exp Med       Date:  2000-05-15       Impact factor: 14.307
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  6 in total

1.  Involvement of streptococcal mitogenic exotoxin Z in streptococcal toxic shock syndrome.

Authors:  Lily Yang; Mark Thomas; Andrew Woodhouse; Diana Martin; John D Fraser; Thomas Proft
Journal:  J Clin Microbiol       Date:  2005-07       Impact factor: 5.948

2.  Longitudinal analysis of the group A Streptococcus transcriptome in experimental pharyngitis in cynomolgus macaques.

Authors:  Kimmo Virtaneva; Stephen F Porcella; Morag R Graham; Robin M Ireland; Claire A Johnson; Stacy M Ricklefs; Imran Babar; Larye D Parkins; Romina A Romero; G Judson Corn; Don J Gardner; John R Bailey; Michael J Parnell; James M Musser
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-14       Impact factor: 11.205

3.  Do cardiomyocytes mount an immune response to Group A Streptococcus?

Authors:  Zhi Li; Amy E Bryant; Stephanie M Hamilton; Clifford R Bayer; Yongsheng Ma; Dennis L Stevens
Journal:  Cytokine       Date:  2011-03-04       Impact factor: 3.861

4.  Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids.

Authors:  Corinne Grangette; Sophie Nutten; Emmanuelle Palumbo; Siegfried Morath; Corinna Hermann; Joelle Dewulf; Bruno Pot; Thomas Hartung; Pascal Hols; Annick Mercenier
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-28       Impact factor: 11.205

5.  Superantigenic activity of emm3 Streptococcus pyogenes is abrogated by a conserved, naturally occurring smeZ mutation.

Authors:  Claire E Turner; Mary Sommerlad; Karen McGregor; Frances J Davies; Bruno Pichon; Deborah L W Chong; Leili Farzaneh; Matthew T G Holden; Brian G Spratt; Androulla Efstratiou; Shiranee Sriskandan
Journal:  PLoS One       Date:  2012-10-01       Impact factor: 3.240

Review 6.  The contribution of group A streptococcal virulence determinants to the pathogenesis of sepsis.

Authors:  Mark Reglinski; Shiranee Sriskandan
Journal:  Virulence       Date:  2013-10-09       Impact factor: 5.882
  6 in total

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