Literature DB >> 21377378

Do cardiomyocytes mount an immune response to Group A Streptococcus?

Zhi Li1, Amy E Bryant, Stephanie M Hamilton, Clifford R Bayer, Yongsheng Ma, Dennis L Stevens.   

Abstract

Some patients with Group A Streptococcal toxic shock syndrome (StrepTSS) develop a unique form of cardiomyopathy characterized by global hypokinesia and reduced cardiac index. Here we investigated the immune responses of cardiomyocytes to Group A Streptococcus both in vivo and in vitro. Our data demonstrate that cardiomyocyte-derived cytokines are produced following both direct GAS stimulation and after exposure to GAS-activated inflammatory cells. These locally produced, cardiomyocyte-derived cytokines may mediate cardiac contractile dysfunction observed in patients with StrepTSS-associated cardiomyopathy and may hold the key to our ability to attenuate this severe complication. Published by Elsevier Ltd.

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Year:  2011        PMID： 21377378      PMCID： PMC3086889          DOI： 10.1016/j.cyto.2011.02.009

Source DB:  PubMed          Journal:  Cytokine        ISSN： 1043-4666            Impact factor:   3.861


  59 in total

1.  Inducible nitric oxide synthase (iNOS) gene deficiency increases the mortality of sepsis in mice.

Authors:  J P Cobb; R S Hotchkiss; P E Swanson; K Chang; Y Qiu; V E Laubach; I E Karl; T G Buchman
Journal:  Surgery       Date:  1999-08       Impact factor: 3.982

Review 2.  Treating patients with severe sepsis.

Authors:  A P Wheeler; G R Bernard
Journal:  N Engl J Med       Date:  1999-01-21       Impact factor: 91.245

3.  HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte.

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Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-17       Impact factor: 11.205

4.  Involvement of inducible nitric oxide synthase in cardiac dysfunction with tumor necrosis factor-alpha.

Authors:  Hajime Funakoshi; Toru Kubota; Yoji Machida; Natsumi Kawamura; Arthur M Feldman; Hiroyuki Tsutsui; Hiroaki Shimokawa; Akira Takeshita
Journal:  Am J Physiol Heart Circ Physiol       Date:  2002-06       Impact factor: 4.733

5.  Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function.

Authors:  B S Cain; D R Meldrum; C A Dinarello; X Meng; K S Joo; A Banerjee; A H Harken
Journal:  Crit Care Med       Date:  1999-07       Impact factor: 7.598

6.  Negative inotropic effects of cytokines on the heart mediated by nitric oxide.

Authors:  M S Finkel; C V Oddis; T D Jacob; S C Watkins; B G Hattler; R L Simmons
Journal:  Science       Date:  1992-07-17       Impact factor: 47.728

7.  iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1.

Authors:  K Bachmaier; N Neu; C Pummerer; G S Duncan; T W Mak; T Matsuyama; J M Penninger
Journal:  Circulation       Date:  1997-07-15       Impact factor: 29.690

8.  In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4.

Authors:  G Baumgarten; P Knuefermann; N Nozaki; N Sivasubramanian; D L Mann; J G Vallejo
Journal:  J Infect Dis       Date:  2001-04-23       Impact factor: 5.226

9.  Expression of intercellular adhesion molecule-1 on cardiac myocytes for myocarditis before and during immunosuppressive therapy.

Authors:  T Toyozaki; T Saito; H Takano; K Yorimitsu; S Kobayashi; H Ichikawa; K Takeda; Y Inagaki
Journal:  Am J Cardiol       Date:  1993-08-15       Impact factor: 2.778

Review 10.  Myocardial contractile dysfunction in the systemic inflammatory response syndrome: role of a cytokine-inducible nitric oxide synthase in cardiac myocytes.

Authors:  D Ungureanu-Longrois; J L Balligand; R A Kelly; T W Smith
Journal:  J Mol Cell Cardiol       Date:  1995-01       Impact factor: 5.000
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  2 in total

1.  Cardiac myocyte dysfunction induced by streptolysin O is membrane pore and calcium dependent.

Authors:  Devin D Bolz; Zhi Li; Eric R McIndoo; Rodney K Tweten; Amy E Bryant; Dennis L Stevens
Journal:  Shock       Date:  2015-02       Impact factor: 3.454

2.  Inflammation, myocardial dysfunction, and mortality in children with septic shock: an observational study.

Authors:  Fabio Carmona; Paulo H Manso; Vanessa S Silveira; Fernando Q Cunha; Margaret de Castro; Ana P C P Carlotti
Journal:  Pediatr Cardiol       Date:  2013-10-04       Impact factor: 1.655
  2 in total

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