PURPOSE: Children with velocardiofacial syndrome (VCFS) often have deficits in mathematical reasoning. Previous research has suggested that structural abnormalities in the parietal lobe region might underlie these deficits. The present study utilized functional magnetic resonance imaging (fMRI) to explore the relationship between brain function and mathematical performance in VCFS. METHODS: Eight children with VCFS and eight comparison subjects underwent fMRI scanning and completed an arithmetic computation task. RESULTS: In the VCFS group, increased activation was observed in the left supramarginal gyrus (LSMG) as the task difficulty increased. CONCLUSION: Aberrant LSMG activation, possibly due to structural deficits of the left parietal lobe, may explain decrements in arithmetic performance observed in VCFS.
PURPOSE: Children with velocardiofacial syndrome (VCFS) often have deficits in mathematical reasoning. Previous research has suggested that structural abnormalities in the parietal lobe region might underlie these deficits. The present study utilized functional magnetic resonance imaging (fMRI) to explore the relationship between brain function and mathematical performance in VCFS. METHODS: Eight children with VCFS and eight comparison subjects underwent fMRI scanning and completed an arithmetic computation task. RESULTS: In the VCFS group, increased activation was observed in the left supramarginal gyrus (LSMG) as the task difficulty increased. CONCLUSION: Aberrant LSMG activation, possibly due to structural deficits of the left parietal lobe, may explain decrements in arithmetic performance observed in VCFS.
Authors: István Akos Mórocz; Firdaus Janoos; Peter van Gelderen; David Manor; Avi Karni; Zvia Breznitz; Michael von Aster; Tammar Kushnir; Ruth Shalev Journal: Int J Imaging Syst Technol Date: 2012-03-01 Impact factor: 2.000
Authors: Doron Gothelf; Amos Frisch; Elena Michaelovsky; Abraham Weizman; Robert J Shprintzen Journal: J Ment Health Res Intellect Disabil Date: 2009-04
Authors: Julio Villalon-Reina; Neda Jahanshad; Elliott Beaton; Arthur W Toga; Paul M Thompson; Tony J Simon Journal: Neuroimage Date: 2013-04-18 Impact factor: 6.556