Literature DB >> 27617156

Potential Role of Cortisol in Social and Memory Impairments in Individuals with 22q11.2 Deletion Syndrome.

Daniel Jacobson1, Megan Bursch2, Renee Lajiness-O'Neill2.   

Abstract

22q11.2 Deletion syndrome is a genetic disorder characterized by physiological and psychological symptoms. This study investigated the role of cortisol on the social and cognitive impairments in children with 22q11.2. A total of 11 children with 22q11.2 were assessed for baseline cortisol levels and received broad neuropsychological testing. Results were compared with 11 controls. Children with 22q11.2 had significantly higher cortisol levels. A significant negative correlation was observed between the general memory and attention/concentration indices of the Wide Range Assessment of Memory and Learning, 2nd edition and cortisol concentrations in the control population. These data provide evidence of a possible causal mechanism that underlies social impairments in stress disorders.

Entities:  

Keywords:  22q.11.2 deletion syndrome; cortisol; neurodevelopmental disorder

Year:  2016        PMID： 27617156      PMCID： PMC4999327          DOI： 10.1055/s-0036-1584549

Source DB:  PubMed          Journal:  J Pediatr Genet        ISSN： 2146-460X


  48 in total

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  4 in total

1.  Working Memory Impairments in Chromosome 22q11.2 Deletion Syndrome: The Roles of Anxiety and Stress Physiology.

Authors:  Ashley F P Sanders; Diana A Hobbs; David D Stephenson; Robert D Laird; Elliott A Beaton
Journal:  J Autism Dev Disord       Date:  2017-04

2.  Exploring associations between diurnal cortisol, stress, coping and psychopathology in adolescents and young adults with 22q11.2 deletion syndrome.

Authors:  Laura Ilen; Clémence Feller; Stephan Eliez; Eva Micol; Farnaz Delavari; Carmen Sandi; Olivia Zanoletti; Maude Schneider
Journal:  Compr Psychoneuroendocrinol       Date:  2021-12-15

3.  Affective and psychotic reactivity to daily-life stress in adults with 22q11DS: a study using the experience sampling method.

Authors:  Maude Schneider; Thomas Vaessen; Esther D A van Duin; Zuzana Kasanova; Wolfgang Viechtbauer; Ulrich Reininghaus; Claudia Vingerhoets; Jan Booij; Ann Swillen; Jacob A S Vorstman; Thérèse van Amelsvoort; Inez Myin-Germeys
Journal:  J Neurodev Disord       Date:  2020-11-13       Impact factor: 4.025

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Authors:  Anushree Tripathi; Michael Spedding; Esther Schenker; Michael Didriksen; Arnaud Cressant; Therese M Jay
Journal:  Transl Psychiatry       Date:  2020-01-28       Impact factor: 6.222
  4 in total

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