| Literature DB >> 11334234 |
B Kroczka1, A Zieba, D Dudek, A Pilc, G Nowak.
Abstract
The effects of zinc, the NMDA receptor inhibitor, were studied in the forced swimming (Porsolt's) test in mice. Zinc (ZnSO4) at a dose of 30 mg/kg (but not at a dose of 10 mg/kg), similarly to imipramine (30 mg/kg), reduced the immobility time in that test. Moreover, zinc at both doses reduced the locomotor activity. The obtained results indicate that zinc induces an antidepressant-like effect in the forced swimming test. Since zinc reduces the locomotor activity, this antidepressant-like effect is not related to the alteration of general activity.Entities:
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Year: 2000 PMID： 11334234
Source DB: PubMed Journal: Pol J Pharmacol ISSN： 1230-6002