Literature DB >> 18766297

Antidepressant-like activity of zinc: further behavioral and molecular evidence.

Magdalena Sowa-Kućma1, Beata Legutko, Bernadeta Szewczyk, Kinga Novak, Paweł Znojek, Ewa Poleszak, Mariusz Papp, Andrzej Pilc, Gabriel Nowak.   

Abstract

Zinc exhibits antidepressant-like activity in preclinical tests (the forced swim test and tail suspension test) and in olfactory bulbectomy and chronic unpredictable stress; two models of depression. Zinc also enhances the treatment of depression in humans. In the present study we evaluated the antidepressant activity of zinc in another model of depression-chronic mild stress (CMS) and the effect of zinc treatment on BDNF protein and the mRNA level. In CMS zinc hydroaspartate (10 mg/kg) exhibited a rapid (after 1 week of treatment) antidepressant-like effect. Chronic treatment with zinc induced a 17-39% increase in the BDNF mRNA and protein level in the hippocampus. These data indicate a rapidly acting antidepressant-like activity of zinc in CMS and the involvement of zinc in the regulation of BDNF.

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Year:  2008        PMID： 18766297     DOI： 10.1007/s00702-008-0115-7

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  40 in total

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