| Literature DB >> 11325954 |
K Ichinose1, T Taguchi, D J Bedford, Y Ebizuka, D A Hopwood.
Abstract
A mutation in actVI-ORF1, which controls C-3 reduction in actinorhodin biosynthesis by Streptomyces coelicolor, was complemented by gra-ORF5 and -ORF6 from the granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22. It is hypothesized that, while gra-ORF5 alone is a ketoreductase for C-9, gra-ORF6 gives the enzyme regiospecificity also for C-3.Entities:
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Year: 2001 PMID： 11325954 PMCID： PMC95226 DOI： 10.1128/JB.183.10.3247-3250.2001
Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490