Literature DB >> 3570987

Biosynthesis of the antibiotic actinorhodin. Analysis of blocked mutants of Streptomyces coelicolor.

S P Cole, B A Rudd, D A Hopwood, C J Chang, H G Floss.   

Abstract

From two types of class V act mutants of Streptomyces coelicolor two monomeric precursors of actinorhodin have been isolated and their structures determined. One is the known antibiotic kalafungin and the other a new compound. Their relationship to actinorhodin biosynthesis is discussed.

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Year:  1987        PMID： 3570987     DOI： 10.7164/antibiotics.40.340

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  14 in total

Review 1.  Thom Award Lecture. Trends in the search for bioactive microbial metabolites.

Authors:  S Omura
Journal:  J Ind Microbiol       Date:  1992-09

2.  Identification of a monooxygenase from Streptomyces coelicolor A3(2) involved in biosynthesis of actinorhodin: purification and characterization of the recombinant enzyme.

Authors:  S G Kendrew; D A Hopwood; E N Marsh
Journal:  J Bacteriol       Date:  1997-07       Impact factor: 3.490

3.  Functional complementation of pyran ring formation in actinorhodin biosynthesis in Streptomyces coelicolor A3(2) by ketoreductase genes for granaticin biosynthesis.

Authors:  K Ichinose; T Taguchi; D J Bedford; Y Ebizuka; D A Hopwood
Journal:  J Bacteriol       Date:  2001-05       Impact factor: 3.490

4.  Organisation and functions of the actVA region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor.

Authors:  J L Caballero; E Martinez; F Malpartida; D A Hopwood
Journal:  Mol Gen Genet       Date:  1991-12

Review 5.  Enantiomeric natural products: occurrence and biogenesis.

Authors:  Jennifer M Finefield; David H Sherman; Martin Kreitman; Robert M Williams
Journal:  Angew Chem Int Ed Engl       Date:  2012-05-03       Impact factor: 15.336

6.  Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions.

Authors:  P L Bartel; C B Zhu; J S Lampel; D C Dosch; N C Connors; W R Strohl; J M Beale; H G Floss
Journal:  J Bacteriol       Date:  1990-09       Impact factor: 3.490

7.  Transcriptional organization and regulation of an antibiotic export complex in the producing Streptomyces culture.

Authors:  J L Caballero; F Malpartida; D A Hopwood
Journal:  Mol Gen Genet       Date:  1991-09

8.  In living color: bacterial pigments as an untapped resource in the classroom and beyond.

Authors:  Louise K Charkoudian; Jay T Fitzgerald; Chaitan Khosla; Andrea Champlin
Journal:  PLoS Biol       Date:  2010-10-05       Impact factor: 8.029

9.  Cloning and analysis of structural genes from Streptomyces pristinaespiralis encoding enzymes involved in the conversion of pristinamycin IIB to pristinamycin IIA (PIIA): PIIA synthase and NADH:riboflavin 5'-phosphate oxidoreductase.

Authors:  V Blanc; D Lagneaux; P Didier; P Gil; P Lacroix; J Crouzet
Journal:  J Bacteriol       Date:  1995-09       Impact factor: 3.490

10.  Mechanism and regulation of the Two-component FMN-dependent monooxygenase ActVA-ActVB from Streptomyces coelicolor.

Authors:  Julien Valton; Carole Mathevon; Marc Fontecave; Vincent Nivière; David P Ballou
Journal:  J Biol Chem       Date:  2008-02-02       Impact factor: 5.157
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