Literature DB >> 10091691

Proof that the ACTVI genetic region of Streptomyces coelicolor A3(2) is involved in stereospecific pyran ring formation in the biosynthesis of actinorhodin.

K Ichinose1, C Surti, T Taguchi, F Malpartida, K I Booker-Milburn, G R Stephenson, Y Ebizuka, D A Hopwood.   

Abstract

Pyran ring formation in the biosynthesis of actinorhodin in Streptomyces coelicolor A3(2) was studied using the act cluster deficient strain, CH999, carrying pRM5-based plasmids harbouring combinations of the actVI genes. The strain, CH999/pIJ5660 (pRM5 + actVI-ORF1), produced a chiral intermediate, (S)-DNPA, suggesting that the actVI-ORF1 product is a reductase determining the C-3 stereochemical centre.

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Year:  1999        PMID： 10091691     DOI： 10.1016/s0960-894x(99)00011-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Functional complementation of pyran ring formation in actinorhodin biosynthesis in Streptomyces coelicolor A3(2) by ketoreductase genes for granaticin biosynthesis.

Authors:  K Ichinose; T Taguchi; D J Bedford; Y Ebizuka; D A Hopwood
Journal:  J Bacteriol       Date:  2001-05       Impact factor: 3.490

Review 2.  Enantiomeric natural products: occurrence and biogenesis.

Authors:  Jennifer M Finefield; David H Sherman; Martin Kreitman; Robert M Williams
Journal:  Angew Chem Int Ed Engl       Date:  2012-05-03       Impact factor: 15.336

3.  Expression of the Streptomyces coelicolor SoxR regulon is intimately linked with actinorhodin production.

Authors:  Rica Dela Cruz; Yang Gao; Sahitya Penumetcha; Rebecca Sheplock; Katherine Weng; Monica Chander
Journal:  J Bacteriol       Date:  2010-10-15       Impact factor: 3.490

Review 4.  Biosynthesis of aromatic polyketides in bacteria.

Authors:  Abhirup Das; Chaitan Khosla
Journal:  Acc Chem Res       Date:  2009-05-19       Impact factor: 22.384

5.  Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis.

Authors:  Nemanja Vuksanovic; Xuechen Zhu; Dante A Serrano; Vilja Siitonen; Mikko Metsä-Ketelä; Charles E Melançon; Nicholas R Silvaggi
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2020-07-29       Impact factor: 1.056

6.  Engineered biosynthesis of the antiparasitic agent frenolicin B and rationally designed analogs in a heterologous host.

Authors:  Jay T Fitzgerald; Christian P Ridley; Chaitan Khosla
Journal:  J Antibiot (Tokyo)       Date:  2011-09-21       Impact factor: 2.649

7.  Acidic pH shock induces the expressions of a wide range of stress-response genes.

Authors:  Yoon Jung Kim; Myung Hee Moon; Jae Yang Song; Colin P Smith; Soon-Kwang Hong; Yong Keun Chang
Journal:  BMC Genomics       Date:  2008-12-16       Impact factor: 3.969

8.  Biosynthesis of Diverse Type II Polyketide Core Structures in Streptomyces coelicolor M1152.

Authors:  Xuechen Zhu; Vilja Siitonen; Charles E Melançon Iii; Mikko Metsä-Ketelä
Journal:  ACS Synth Biol       Date:  2021-01-20       Impact factor: 5.110
  8 in total

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