BACKGROUND: Hemp dust exposure is associated with byssinosis and accelerated lung loss in longitudinal studies. The immunological changes associated with hemp dust exposure are less well understood. METHODS: We studied a small group of current male hemp processors with a mean age of 43 years. Questionnaire data, lung function, serial FEV(1) and blood were collected from all workers. RESULTS: In total, seven workers (64%) complained of at least one respiratory symptom (one with byssinosis). The mean percentage predicted FEV(1) was 91.5, FVC 97.7, PEF 92.1, and FEF(25-75) 79.5. Serial FEV(1) measurements in the two workers with work-related respiratory symptoms revealed a mean change in FEV(1) on the first working day of -12.9%. This contrasted with +6.25% on the last working day. Respective values for the two workers without work-related symptoms were -1.4 and +3.2%. CONCLUSIONS: Lung function changes and abnormalities in a profile of cell surface activation markers and antibodies were noted to relate to the presence of work-related respiratory symptoms, not seen in the control group.
BACKGROUND:Hemp dust exposure is associated with byssinosis and accelerated lung loss in longitudinal studies. The immunological changes associated with hemp dust exposure are less well understood. METHODS: We studied a small group of current male hemp processors with a mean age of 43 years. Questionnaire data, lung function, serial FEV(1) and blood were collected from all workers. RESULTS: In total, seven workers (64%) complained of at least one respiratory symptom (one with byssinosis). The mean percentage predicted FEV(1) was 91.5, FVC 97.7, PEF 92.1, and FEF(25-75) 79.5. Serial FEV(1) measurements in the two workers with work-related respiratory symptoms revealed a mean change in FEV(1) on the first working day of -12.9%. This contrasted with +6.25% on the last working day. Respective values for the two workers without work-related symptoms were -1.4 and +3.2%. CONCLUSIONS: Lung function changes and abnormalities in a profile of cell surface activation markers and antibodies were noted to relate to the presence of work-related respiratory symptoms, not seen in the control group.
Authors: Ine I Decuyper; Brett J Green; Gordon L Sussman; Didier G Ebo; William S Silvers; Karin Pacheco; Bradley S King; John R Cohn; Robert S Zeiger; Joanna S Zeiger; David R Naimi; Donald H Beezhold; Ajay P Nayak Journal: J Allergy Clin Immunol Pract Date: 2020 Nov - Dec
Authors: Brynne Silvey; Edmund Seto; Alexander Gipe; Niloufar Ghodsian; Christopher D Simpson Journal: Ann Work Expo Health Date: 2020-08-06 Impact factor: 2.179
Authors: James R Couch; George Reed Grimes; Brett J Green; Douglas M Wiegand; Bradley King; Mark M Methner Journal: Ann Work Expo Health Date: 2020-08-06 Impact factor: 2.179
Authors: Maggie Davidson; Sue Reed; Jacques Oosthuizen; Greg O'Donnell; Pragna Gaur; Martyn Cross; Gary Dennis Journal: Int J Occup Environ Health Date: 2018-10-03
Authors: Brett J Green; James R Couch; Angela R Lemons; Nancy C Burton; Kerton R Victory; Ajay P Nayak; Donald H Beezhold Journal: J Occup Environ Hyg Date: 2018-05 Impact factor: 2.155
Authors: Karen B Mulloy; Steven A Sumner; Cecile Rose; George A Conway; Stephen J Reynolds; Margaret E Davidson; Donna S Heidel; Peter M Layde Journal: Am J Ind Med Date: 2013-08-31 Impact factor: 3.079
Authors: James R Couch; George R Grimes; Douglas M Wiegand; Brett J Green; Eric K Glassford; Leonard M Zwack; Angela R Lemons; Stephen R Jackson; Donald H Beezhold Journal: Am J Ind Med Date: 2019-07-23 Impact factor: 3.079