OBJECTIVE: To assess the genetic contribution to determinants of therapeutic weight loss in obese female identical twins. DESIGN: Subjects were studied for 40 days on an inpatient unit in three phases: 7 baseline days; 28 days of weight reduction by a very low calorie diet (1.6 MJ per day); and 5 days after weight reduction. SUBJECTS: Fourteen pairs of premenopausal obese female identical twins (age: 39.0+/-1.7 y; body weight (BW): 93.9+/-21.2 kg; body mass index (BMI): 34.2+/-7.8 kg/m2). MEASUREMENTS: : Body composition by hydrodensitometry and resting metabolic rate by indirect calorimetry were assessed before and after weight loss. RESULTS: : There was great variability among pairs in loss of weight (5.9-12.4 kg) and body fat (3.1-12.4 kg). By contrast, the intraclass correlation (ICC) within twin pairs was 0.85, P<0.001 for weight and 0.88, P<0.001 for body fat. A measure of metabolic efficiency, calculated as the difference between 'estimated' and 'measured' energy deficit showed high intrapair correlation (ICC=0.77; P<0.001). CONCLUSIONS: The high correlation in metabolic efficiency within twin pairs in response to therapeutic weight loss suggests a strong genetic contribution.
OBJECTIVE: To assess the genetic contribution to determinants of therapeutic weight loss in obese female identical twins. DESIGN: Subjects were studied for 40 days on an inpatient unit in three phases: 7 baseline days; 28 days of weight reduction by a very low calorie diet (1.6 MJ per day); and 5 days after weight reduction. SUBJECTS: Fourteen pairs of premenopausal obese female identical twins (age: 39.0+/-1.7 y; body weight (BW): 93.9+/-21.2 kg; body mass index (BMI): 34.2+/-7.8 kg/m2). MEASUREMENTS: : Body composition by hydrodensitometry and resting metabolic rate by indirect calorimetry were assessed before and after weight loss. RESULTS: : There was great variability among pairs in loss of weight (5.9-12.4 kg) and body fat (3.1-12.4 kg). By contrast, the intraclass correlation (ICC) within twin pairs was 0.85, P<0.001 for weight and 0.88, P<0.001 for body fat. A measure of metabolic efficiency, calculated as the difference between 'estimated' and 'measured' energy deficit showed high intrapair correlation (ICC=0.77; P<0.001). CONCLUSIONS: The high correlation in metabolic efficiency within twin pairs in response to therapeutic weight loss suggests a strong genetic contribution.
Authors: Lawrence Kazak; Edward T Chouchani; Gina Z Lu; Mark P Jedrychowski; Curtis J Bare; Amir I Mina; Manju Kumari; Song Zhang; Ivan Vuckovic; Dina Laznik-Bogoslavski; Petras Dzeja; Alexander S Banks; Evan D Rosen; Bruce M Spiegelman Journal: Cell Metab Date: 2017-08-24 Impact factor: 27.287
Authors: Jennifer A Nettleton; Jack L Follis; Julius S Ngwa; Caren E Smith; Shafqat Ahmad; Toshiko Tanaka; Mary K Wojczynski; Trudy Voortman; Rozenn N Lemaitre; Kati Kristiansson; Marja-Liisa Nuotio; Denise K Houston; Mia-Maria Perälä; Qibin Qi; Emily Sonestedt; Ani Manichaikul; Stavroula Kanoni; Andrea Ganna; Vera Mikkilä; Kari E North; David S Siscovick; Kennet Harald; Nicola M Mckeown; Ingegerd Johansson; Harri Rissanen; Yongmei Liu; Jari Lahti; Frank B Hu; Stefania Bandinelli; Gull Rukh; Stephen Rich; Lisanne Booij; Maria Dmitriou; Erika Ax; Olli Raitakari; Kenneth Mukamal; Satu Männistö; Göran Hallmans; Antti Jula; Ulrika Ericson; David R Jacobs; Frank J A Van Rooij; Panos Deloukas; Per Sjögren; Mika Kähönen; Luc Djousse; Markus Perola; Inês Barroso; Albert Hofman; Kathleen Stirrups; Jorma Viikari; André G Uitterlinden; Ioanna P Kalafati; Oscar H Franco; Dariush Mozaffarian; Veikko Salomaa; Ingrid B Borecki; Paul Knekt; Stephen B Kritchevsky; Johan G Eriksson; George V Dedoussis; Lu Qi; Luigi Ferrucci; Marju Orho-Melander; M Carola Zillikens; Erik Ingelsson; Terho Lehtimäki; Frida Renström; L Adrienne Cupples; Ruth J F Loos; Paul W Franks Journal: Hum Mol Genet Date: 2015-05-20 Impact factor: 6.150
Authors: Michael Rosenbaum; Tanya Agurs-Collins; Molly S Bray; Kevin D Hall; Mark Hopkins; Maren Laughlin; Paul S MacLean; Padma Maruvada; Cary R Savage; Dana M Small; Luke Stoeckel Journal: Obesity (Silver Spring) Date: 2018-04 Impact factor: 5.002