Literature DB >> 112999

Strain differences in rat liver (UDP-glucuronyltransferase activity towards androsterone.

M Matsui, F Nagai, S Aoyagi.   

Abstract

Male Donryu, Wistar King rats showed discontinuous variations in hepatic microsomal UDP-glucuronyltransferase activities towards androsterone, but not towards testosterone, bilirubin, phenolphthalein and 4-nitrophenol. Fresh microsomal fraction with a low transferase activity towards androsterone formed 0.049--0.080 nmole of glucuronide/min per mg of protein, whereas fresh microsomal fraction with a high transferase activity towards androsterone formed 0.335--0.557 nmol of glucuronide/min per mg of protein. The microsomal fraction with low enzyme activity towards androsterone was not stimulated by treatment with Triton X-100 or freezing and thawing. In contrast, male Long Evans and Sprague-Dawley rats did not exhibit such diversity.

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Year:  1979        PMID： 112999      PMCID： PMC1186654          DOI： 10.1042/bj1790483

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  Discontinuous variation in hepatic uridine diphosphate glucuronyltransferase toward androsterone in Wistar rats. A regulatory factor for in vivo metabolism of androsterone.

Authors:  M Matsui; M Hakozaki
Journal:  Biochem Pharmacol       Date:  1979       Impact factor: 5.858

2.  Functional heterogeneity of UDP-glucuronosyltransferase as indicated by its differential development and inducibility by glucocorticoids. Demonstration of two groups within the enzyme's activity towards twelve substrates.

Authors:  G J Wishart
Journal:  Biochem J       Date:  1978-08-15       Impact factor: 3.857

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Biliary metabolites of testosterone and testosterone glucosiduronate in the rat.

Authors:  M Matsui; Y Kinuyama; M Hakozaki
Journal:  Steroids       Date:  1974-10       Impact factor: 2.668

5.  Reactivation of a pure defective UDP-glucuronyltransferase from homozygous Gunn rat liver.

Authors:  P J Weatherill; B Burchell
Journal:  FEBS Lett       Date:  1978-03-15       Impact factor: 4.124

6.  Separation and partial purification of two differentially inducible UDP-glucuronyltransferases from rat liver.

Authors:  K W Bock; U C von Clausbruch; D Josting; H Ottenwälder
Journal:  Biochem Pharmacol       Date:  1977-06-01       Impact factor: 5.858

7.  Studies on the properties of an enzyme forming the glucuronide of pregnanediol and the pattern of development of steroid glucuronyltransferases in rat liver.

Authors:  M Fuchs; G S Rao; M L Rao; H Breuer
Journal:  J Steroid Biochem       Date:  1977-03       Impact factor: 4.292

8.  Substrate specificity and properties of uridine diphosphate glucuronyltransferase purified to apparent homogeneity from phenobarbital-treated rat liver.

Authors:  B Burchell
Journal:  Biochem J       Date:  1978-09-01       Impact factor: 3.857

9.  Determination of bilirubin glucuronide and assay of glucuronyltransferase with bilirubin as acceptor.

Authors:  F P Van Roy; K P Heirwegh
Journal:  Biochem J       Date:  1968-04       Impact factor: 3.857

10.  Steroid and non-steroid UDP glucuronyltransferase: glucuronidation of synthetic estrogens as steroids.

Authors:  G W Lucier; O S McDaniel
Journal:  J Steroid Biochem       Date:  1977-08       Impact factor: 4.292
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  8 in total

1.  Genetic deficiency of androsterone UDP-glucuronosyltransferase activity in Wistar rats is due to the loss of enzyme protein.

Authors:  M Matsui; F Nagai
Journal:  Biochem J       Date:  1986-02-15       Impact factor: 3.857

2.  The full length coding sequence of rat liver androsterone UDP-glucuronyltransferase cDNA and comparison with other members of this gene family.

Authors:  M R Jackson; B Burchell
Journal:  Nucleic Acids Res       Date:  1986-01-24       Impact factor: 16.971

3.  Effects of steroid hormones and xenobiotics on the pubertal development of UDP-glucuronosyltransferase activities towards androsterone and 4-nitrophenol in Wistar rats.

Authors:  H K Watanabe; M Matsui
Journal:  Biochem J       Date:  1984-09-01       Impact factor: 3.857

4.  Studies on the genetic linkage of bilirubin and androsterone UDP-glucuronyltransferases by cross-breeding of two mutant rat strains.

Authors:  F Nagai; H Homma; H Tanase; M Matsui
Journal:  Biochem J       Date:  1988-06-15       Impact factor: 3.857

5.  Developmental alteration of hepatic UDP-glucuronosyltransferase and sulphotransferase towards androsterone and 4-nitrophenol in Wistar rats.

Authors:  M Matsui; H K Watanabe
Journal:  Biochem J       Date:  1982-05-15       Impact factor: 3.857

6.  Classification and genetic expression of Wistar rats with high and low hepatic microsomal UDP-glucuronosyltransferase activity towards androsterone.

Authors:  M Matsui; H K Watanabe
Journal:  Biochem J       Date:  1982-01-15       Impact factor: 3.857

7.  Isolation of cDNAs for mouse phenol and bilirubin UDP-glucuronosyltransferases and mapping of the mouse gene for phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by restriction fragment length variations.

Authors:  O Koiwai; K Hasada; Y Yasui; Y Sakai; H Sato; T Watanabe
Journal:  Biochem Genet       Date:  1995-04       Impact factor: 1.890

8.  Strain differences in purified rat hepatic 3 alpha-hydroxysteroid UDP-glucuronosyltransferase.

Authors:  M D Green; C N Falany; R B Kirkpatrick; T R Tephly
Journal:  Biochem J       Date:  1985-09-01       Impact factor: 3.857
  8 in total

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