| Literature DB >> 11296312 |
L Rowland1, J R Bustillo, J Lauriello.
Abstract
Proton magnetic resonance spectroscopy ((1)H-MRS) is a noninvasive technique that can quantify biochemical compounds in the brain. (1)H-MRS has been used to investigate neural structures implicated in the pathology of schizophrenia. The majority of research has revealed reduced N-acetylaspartate (NAA), an index of neuronal integrity, in frontal and temporal regions of medicated and chronically ill patients with schizophrenia. This review summarizes basic principles of (1)H-MRS, studies of frontal, temporal, subcortical, and cerebellar regions in schizophrenia. Technical and study design limitations are also discussed. Copyright 2001 by W.B. Saunders Company.Entities:
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Year: 2001 PMID： 11296312 DOI： 10.1053/scnp.2001.21838
Source DB: PubMed Journal: Semin Clin Neuropsychiatry ISSN： 1084-3612