OBJECTIVES: To evaluate whether induced dental pain leads to quantitative changes in brain metabolites within the left insular cortex after stimulation of the right maxillary canine and to examine whether these metabolic changes and the subjective pain intensity perception correlate. METHODS: Ten male volunteers were included in the pain group and compared with a control group of 10 other healthy volunteers. The pain group received a total of 87-92 electrically induced pain stimuli over 15 min to the right maxillary canine tooth. Contemporaneously, they evaluated the subjective pain intensity of every stimulus using an analogue scale. Neurotransmitter changes within the left insular cortex were evaluated by MR spectroscopy. RESULTS: Significant metabolic changes in glutamine (+55.1%), glutamine/glutamate (+16.4%) and myo-inositol (-9.7%) were documented during pain stimulation. Furthermore, there was a significant negative correlation between the subjective pain intensity perception and the metabolic levels of Glx, Gln, glutamate and N-acetyl aspartate. CONCLUSION: The insular cortex is a metabolically active region in the processing of acute dental pain. Induced dental pain leads to quantitative changes in brain metabolites within the left insular cortex resulting in significant alterations in metabolites. Negative correlation between subjective pain intensity rating and specific metabolites could be observed.
OBJECTIVES: To evaluate whether induced dental pain leads to quantitative changes in brain metabolites within the left insular cortex after stimulation of the right maxillary canine and to examine whether these metabolic changes and the subjective pain intensity perception correlate. METHODS: Ten male volunteers were included in the pain group and compared with a control group of 10 other healthy volunteers. The pain group received a total of 87-92 electrically induced pain stimuli over 15 min to the right maxillary canine tooth. Contemporaneously, they evaluated the subjective pain intensity of every stimulus using an analogue scale. Neurotransmitter changes within the left insular cortex were evaluated by MR spectroscopy. RESULTS: Significant metabolic changes in glutamine (+55.1%), glutamine/glutamate (+16.4%) and myo-inositol (-9.7%) were documented during pain stimulation. Furthermore, there was a significant negative correlation between the subjective pain intensity perception and the metabolic levels of Glx, Gln, glutamate and N-acetyl aspartate. CONCLUSION: The insular cortex is a metabolically active region in the processing of acute dental pain. Induced dental pain leads to quantitative changes in brain metabolites within the left insular cortex resulting in significant alterations in metabolites. Negative correlation between subjective pain intensity rating and specific metabolites could be observed.
Authors: Paul Dunckley; Richard G Wise; Merle Fairhurst; Peter Hobden; Qasim Aziz; Lin Chang; Irene Tracey Journal: J Neurosci Date: 2005-08-10 Impact factor: 6.167
Authors: G D Iannetti; L Zambreanu; R G Wise; T J Buchanan; J P Huggins; T S Smart; W Vennart; I Tracey Journal: Proc Natl Acad Sci U S A Date: 2005-12-05 Impact factor: 11.205
Authors: R Peyron; L García-Larrea; M C Grégoire; P Convers; A Richard; F Lavenne; F G Barral; F Mauguière; D Michel; B Laurent Journal: Pain Date: 2000-01 Impact factor: 6.961
Authors: Michael Valet; Harald Gündel; Till Sprenger; Christian Sorg; Mark Mühlau; Claus Zimmer; Peter Henningsen; Thomas R Tölle Journal: Psychosom Med Date: 2008-12-10 Impact factor: 4.312
Authors: Nicolas Fayed; Javier Garcia-Campayo; Rosa Magallón; Helena Andrés-Bergareche; Juan V Luciano; Eva Andres; Julián Beltrán Journal: Arthritis Res Ther Date: 2010-07-07 Impact factor: 5.156
Authors: Yury Koush; Douglas L Rothman; Kevin L Behar; Robin A de Graaf; Fahmeed Hyder Journal: J Cereb Blood Flow Metab Date: 2022-01-26 Impact factor: 6.960
Authors: Andreas Gutzeit; Dieter Meier; Johannes M Froehlich; Klaus Hergan; Sebastian Kos; Constantin V Weymarn; Kai Lutz; Dominik Ettlin; Christoph A Binkert; Jochen Mutschler; Sabine Sartoretti-Schefer; Mike Brügger Journal: Eur Radiol Date: 2012-09-12 Impact factor: 5.315
Authors: Gerard Eric Dwyer; Alexander R Craven; Justyna Bereśniewicz; Katarzyna Kazimierczak; Lars Ersland; Kenneth Hugdahl; Renate Grüner Journal: Front Hum Neurosci Date: 2021-03-24 Impact factor: 3.169
Authors: Michael L Meier; Nuno M P de Matos; Mike Brügger; Dominik A Ettlin; Nenad Lukic; Marcus Cheetham; Lutz Jäncke; Kai Lutz Journal: Front Hum Neurosci Date: 2014-07-18 Impact factor: 3.169
Authors: Eric A Woodcock; Chaitali Anand; Dalal Khatib; Vaibhav A Diwadkar; Jeffrey A Stanley Journal: Front Psychiatry Date: 2018-03-06 Impact factor: 4.157