Literature DB >> 25614132

In vivo assessment of neurotransmitters and modulators with magnetic resonance spectroscopy: application to schizophrenia.

S Andrea Wijtenburg1, Shaolin Yang2, Bernard A Fischer3, Laura M Rowland4.   

Abstract

In vivo measurement of neurotransmitters and modulators is now feasible with advanced proton magnetic resonance spectroscopy ((1)H MRS) techniques. This review provides a basic tutorial of MRS, describes the methods available to measure brain glutamate, glutamine, γ-aminobutyric acid, glutathione, N-acetylaspartylglutamate, glycine, and serine at magnetic field strengths of 3T or higher, and summarizes the neurochemical findings in schizophrenia. Overall, (1)H MRS holds great promise for producing biomarkers that can serve as treatment targets, prediction of disease onset, or illness exacerbation in schizophrenia and other brain diseases.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  GABA; Glutamate; Glutathione; Magnetic resonance spectroscopy; Schizophrenia

Mesh：

Year:  2015        PMID： 25614132      PMCID： PMC4427237          DOI： 10.1016/j.neubiorev.2015.01.007

Source DB:  PubMed          Journal:  Neurosci Biobehav Rev        ISSN： 0149-7634            Impact factor:   8.989


  178 in total

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Authors:  Dick J Drost; William R Riddle; Geoffrey D Clarke
Journal:  Med Phys       Date:  2002-09       Impact factor: 4.071

2.  N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells.

Authors:  B Wroblewska; J T Wroblewski; S Pshenichkin; A Surin; S E Sullivan; J H Neale
Journal:  J Neurochem       Date:  1997-07       Impact factor: 5.372

3.  In vivo 1H NMR spectroscopy of the human brain at 9.4 T: initial results.

Authors:  Dinesh Kumar Deelchand; Pierre-François Van de Moortele; Gregor Adriany; Isabelle Iltis; Peter Andersen; John P Strupp; J Thomas Vaughan; Kâmil Uğurbil; Pierre-Gilles Henry
Journal:  J Magn Reson       Date:  2010-06-10       Impact factor: 2.229

4.  Very short echo time improves the precision of glutamate detection at 3T in 1H magnetic resonance spectroscopy.

Authors:  S Andrea Wijtenburg; Jack Knight-Scott
Journal:  J Magn Reson Imaging       Date:  2011-07-14       Impact factor: 4.813

5.  Anterior cingulate glutamate levels related to clinical status following treatment in first-episode schizophrenia.

Authors:  Alice Egerton; Stefan Brugger; Marie Raffin; Gareth J Barker; David J Lythgoe; Philip K McGuire; James M Stone
Journal:  Neuropsychopharmacology       Date:  2012-07-04       Impact factor: 7.853

6.  Creatine abnormalities in schizophrenia and bipolar disorder.

Authors:  Dost Ongür; Andrew P Prescot; J Eric Jensen; Bruce M Cohen; Perry F Renshaw
Journal:  Psychiatry Res       Date:  2009-02-23       Impact factor: 3.222

7.  Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS.

Authors:  Jean Théberge; Yousef Al-Semaan; Peter C Williamson; Ravi S Menon; Richard W J Neufeld; Nagalingam Rajakumar; Betsy Schaefer; Maria Densmore; Dick J Drost
Journal:  Am J Psychiatry       Date:  2003-12       Impact factor: 18.112

8.  Multimodal analysis of the hippocampus in schizophrenia using proton magnetic resonance spectroscopy and functional magnetic resonance imaging.

Authors:  Nathan L Hutcheson; Meredith A Reid; David M White; Nina V Kraguljac; Kathy B Avsar; Mark S Bolding; Robert C Knowlton; Jan A den Hollander; Adrienne C Lahti
Journal:  Schizophr Res       Date:  2012-07-23       Impact factor: 4.939

9.  Measurement of reduced glutathione (GSH) in human brain using LCModel analysis of difference-edited spectra.

Authors:  Melissa Terpstra; Pierre-Gilles Henry; Rolf Gruetter
Journal:  Magn Reson Med       Date:  2003-07       Impact factor: 4.668

10.  White matter alterations in deficit schizophrenia.

Authors:  Laura M Rowland; Elena A Spieker; Alan Francis; Peter B Barker; William T Carpenter; Robert W Buchanan
Journal:  Neuropsychopharmacology       Date:  2008-12-03       Impact factor: 7.853
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  33 in total

1.  Sulforaphane Augments Glutathione and Influences Brain Metabolites in Human Subjects: A Clinical Pilot Study.

Authors:  Thomas W Sedlak; Leslie G Nucifora; Minori Koga; Lindsay S Shaffer; Cecilia Higgs; Teppei Tanaka; Anna M Wang; Jennifer M Coughlin; Peter B Barker; Jed W Fahey; Akira Sawa
Journal:  Mol Neuropsychiatry       Date:  2018-04-17

2.  Glutamatergic Metabolites, Volume and Cortical Thickness in Antipsychotic-Naive Patients with First-Episode Psychosis: Implications for Excitotoxicity.

Authors:  Eric Plitman; Raihaan Patel; Jun Ku Chung; Jon Pipitone; Sofia Chavez; Francisco Reyes-Madrigal; Gladys Gómez-Cruz; Pablo León-Ortiz; M Mallar Chakravarty; Camilo de la Fuente-Sandoval; Ariel Graff-Guerrero
Journal:  Neuropsychopharmacology       Date:  2016-06-08       Impact factor: 7.853

3.  A Neural "Tuning Curve" for Multisensory Experience and Cognitive-Perceptual Schizotypy.

Authors:  Francesca Ferri; Yuliya S Nikolova; Mauro Gianni Perrucci; Marcello Costantini; Antonio Ferretti; Valentina Gatta; Zirui Huang; Richard A E Edden; Qiang Yue; Marco D'Aurora; Etienne Sibille; Liborio Stuppia; Gian Luca Romani; Georg Northoff
Journal:  Schizophr Bull       Date:  2017-07-01       Impact factor: 9.306

4.  Age-related changes in anterior cingulate cortex glutamate in schizophrenia: A (1)H MRS Study at 7 Tesla.

Authors:  Allison S Brandt; Paul G Unschuld; Subechhya Pradhan; Issel Anne L Lim; Gregory Churchill; Ashley D Harris; Jun Hua; Peter B Barker; Christopher A Ross; Peter C M van Zijl; Richard A E Edden; Russell L Margolis
Journal:  Schizophr Res       Date:  2016-02-28       Impact factor: 4.939

5.  A semiadiabatic spectral-spatial spectroscopic imaging (SASSI) sequence for improved high-field MR spectroscopic imaging.

Authors:  Rebecca E Feldman; Priti Balchandani
Journal:  Magn Reson Med       Date:  2015-10-31       Impact factor: 4.668

Review 6.  Gamma band oscillations: a key to understanding schizophrenia symptoms and neural circuit abnormalities.

Authors:  James M McNally; Robert W McCarley
Journal:  Curr Opin Psychiatry       Date:  2016-05       Impact factor: 4.741

7.  Brain metabolic alterations in mice subjected to postnatal traumatic stress and in their offspring.

Authors:  Katharina Gapp; Alberto Corcoba; Gretchen van Steenwyk; Isabelle M Mansuy; João Mn Duarte
Journal:  J Cereb Blood Flow Metab       Date:  2016-01-01       Impact factor: 6.200

8.  Salivary kynurenic acid response to psychological stress: inverse relationship to cortical glutamate in schizophrenia.

Authors:  Joshua Chiappelli; Laura M Rowland; Francesca M Notarangelo; S Andrea Wijtenburg; Marian A R Thomas; Ana Pocivavsek; Aaron Jones; Krista Wisner; Peter Kochunov; Robert Schwarcz; L Elliot Hong
Journal:  Neuropsychopharmacology       Date:  2018-04-18       Impact factor: 7.853

9.  Glutamatergic metabolites are associated with visual plasticity in humans.

Authors:  S Andrea Wijtenburg; Jeffrey West; Stephanie A Korenic; Franchesca Kuhney; Frank E Gaston; Hongji Chen; Meredith Roberts; Peter Kochunov; L Elliot Hong; Laura M Rowland
Journal:  Neurosci Lett       Date:  2017-02-10       Impact factor: 3.046

10.  Elevated Myo-Inositol, Choline, and Glutamate Levels in the Associative Striatum of Antipsychotic-Naive Patients With First-Episode Psychosis: A Proton Magnetic Resonance Spectroscopy Study With Implications for Glial Dysfunction.

Authors:  Eric Plitman; Camilo de la Fuente-Sandoval; Francisco Reyes-Madrigal; Sofia Chavez; Gladys Gómez-Cruz; Pablo León-Ortiz; Ariel Graff-Guerrero
Journal:  Schizophr Bull       Date:  2015-08-28       Impact factor: 9.306
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