Literature DB >> 1129258

Myocardial extraction of labeled long-chain fatty acid analogs (38509).

N D Poe, G D Rovinson, N S MacDonald.   

Abstract

The single circulation myocardial extraction of terminally iodinated hexadecenoic acid (77 plus or minus 11.0%) is approximately two times the extraction of 18 carbon fatty acids (33 plus or minus 5.2%) prepared by iodination of double bonds. The results compare favorably with natural 28 carbon steraic (70 plus or minus 7.5%) and oleic (61 plus or minus 7.8%) acids labeled with carbon-11 in the carboxyl group. It is concluded that terminally radioiodinated long chain fatty acids can be used as substitues for in vivo investigations of fatty acid distribution and in particular may be useful as a regional mycardial blood flow indicator.

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Year:  1975        PMID: 1129258     DOI: 10.3181/00379727-148-38509

Source DB:  PubMed          Journal:  Proc Soc Exp Biol Med        ISSN: 0037-9727


  11 in total

1.  Regional rates of myocardial fatty acid metabolism: comparison with coronary angiography and ventriculography.

Authors:  N Schad; R K Wagner; J Hallermeier; H J Daus; A Vattimo; P Bertelli
Journal:  Eur J Nucl Med       Date:  1990

Review 2.  Iodine-123-labelled fatty acids for myocardial single-photon emission tomography: current status and future perspectives.

Authors:  F F Knapp; J Kropp
Journal:  Eur J Nucl Med       Date:  1995-04

3.  The elimination rate of 123I-heptadecanoic acid after intracoronary and intravenous administration.

Authors:  F C Visser; M J van Eenige; E E van der Wall; G Westera; C J van Engelen; A van Lingen; C C de Cock; W den Hollander; G A Heidendal; J P Roos
Journal:  Eur J Nucl Med       Date:  1985

4.  Tellurium-labeled fatty-acid analogs: relationship of heteroatom position to myocardial kinetics.

Authors:  R D Okada; F F Knapp; M M Goodman; D Elmaleh; H W Strauss
Journal:  Eur J Nucl Med       Date:  1985

5.  Comparison of 16-iodohexadecanoic acid (IHDA) and 15-p-iodophenylpentadecanoic acid (IPPA) metabolism and kinetics in the isolated rat heart.

Authors:  T R DeGrado; J E Holden; C K Ng; D M Raffel; S J Gatley
Journal:  Eur J Nucl Med       Date:  1988

6.  Beta-oxidation of 1-[14C]-17-[131I]-iodo-heptadecanoic acid following intracoronary injection in humans results in similar release of both tracers.

Authors:  M M Henrich; K Grossmann; W Motz; M Vogt; E Vester; M Holschbach; W Hamkens; G Notohamiprodjo; B E Strauer; L E Feinendegen
Journal:  Eur J Nucl Med       Date:  1993-03

7.  Biochemical concept and synthesis of a radioiodinated phenylfatty acid for in vivo metabolic studies of the myocardium.

Authors:  H J Machulla; M Marsmann; K Dutschka
Journal:  Eur J Nucl Med       Date:  1980-04

8.  A comparison between terminally radioiodinated hexadecenoic acid (125I-HA) and heptadecanoic acid (131I-H0A) in the dog heart.

Authors:  E E van der Wall; G Westera; G A Heidendal; W den Hollander
Journal:  Eur J Nucl Med       Date:  1981-12

9.  Metabolism of methyl-branched iodo palmitic acids in cultured hepatocytes.

Authors:  G Thomas; D Pépin; C Loriette; M Vidal; M Apparu; S Coornaert; J Chambaz; G Béréziat
Journal:  Eur J Nucl Med       Date:  1989

10.  I-123 heptadecanoic acid--value and limitations in comparison with C-11 palmitate.

Authors:  H R Schön
Journal:  Eur J Nucl Med       Date:  1986
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