Literature DB >> 11286794

Possible modes of action of the artemisinin-type compounds.

P L Olliaro1, R K Haynes, B Meunier, Y Yuthavong.   

Abstract

Artemisinin-type compounds are used for the treatment of uncomplicated and severe forms of malaria. They reduce parasitaemia more rapidly than any other antimalarial compound known, and are effective against multidrug-resistant parasites. However, uncertainties remain as to how they act on the parasite and cause toxicity. In this review, we summarize current ideas.

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Year:  2001        PMID： 11286794     DOI： 10.1016/s1471-4922(00)01838-9

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  45 in total

1.  Artemisinin antimalarials do not inhibit hemozoin formation.

Authors:  Richard K Haynes; Diego Monti; Donatella Taramelli; Nicoletta Basilico; Silvia Parapini; Piero Olliaro
Journal:  Antimicrob Agents Chemother       Date:  2003-03       Impact factor: 5.191

2.  Growth-inhibitory effects of artesunate, pyrimethamine, and pamaquine against Babesia equi and Babesia caballi in in vitro cultures.

Authors:  Akiko Nagai; Naoaki Yokoyama; Tomohide Matsuo; Sabine Bork; Haruyuki Hirata; Xuenan Xuan; Yinchang Zhu; Florencia G Claveria; Kozo Fujisaki; Ikuo Igarashi
Journal:  Antimicrob Agents Chemother       Date:  2003-02       Impact factor: 5.191

3.  Artemisinin and heme.

Authors:  Steven R Meshnick
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191

4.  The antimalarial drug artemisinin alkylates heme in infected mice.

Authors:  Anne Robert; Françoise Benoit-Vical; Catherine Claparols; Bernard Meunier
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-09       Impact factor: 11.205

5.  Trioxaquines and heme-artemisinin adducts inhibit the in vitro formation of hemozoin better than chloroquine.

Authors:  Christophe Loup; Joël Lelièvre; Françoise Benoit-Vical; Bernard Meunier
Journal:  Antimicrob Agents Chemother       Date:  2007-08-13       Impact factor: 5.191

6.  Cysteamine, the molecule used to treat cystinosis, potentiates the antimalarial efficacy of artemisinin.

Authors:  Gundula Min-Oo; Anny Fortin; Jean-François Poulin; Philippe Gros
Journal:  Antimicrob Agents Chemother       Date:  2010-05-17       Impact factor: 5.191

Review 7.  Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria.

Authors:  Richard T Eastman; David A Fidock
Journal:  Nat Rev Microbiol       Date:  2009-11-02       Impact factor: 60.633

8.  Selection of a trioxaquine as an antimalarial drug candidate.

Authors:  Frédéric Coslédan; Laurent Fraisse; Alain Pellet; François Guillou; Benjamin Mordmüller; Peter G Kremsner; Alicia Moreno; Dominique Mazier; Jean-Pierre Maffrand; Bernard Meunier
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-05       Impact factor: 11.205

9.  Artemisinin effectiveness in erythrocytes is reduced by heme and heme-containing proteins.

Authors:  Napawan Ponmee; Tatsanee Chuchue; Prapon Wilairat; Yongyuth Yuthavong; Sumalee Kamchonwongpaisan
Journal:  Biochem Pharmacol       Date:  2007-03-15       Impact factor: 5.858

10.  Characterization of noncovalent complexes of antimalarial agents of the artemisinin-type and FE(III)-heme by electrospray mass spectrometry and collisional activation tandem mass spectrometry.

Authors:  Vlada A Pashynska; Hilde Van den Heuvel; Magda Claeys; Marina V Kosevich
Journal:  J Am Soc Mass Spectrom       Date:  2004-08       Impact factor: 3.109
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